ArticleNorth American journal of medical sciences2011
Role of TIM-4 in innate or adaptive immune response.
Article in North American journal of medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families.Frontiers in immunology · 2025Review
- Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review.Frontiers in molecular biosciences · 2023Review
- Immune Regulation and Antitumor Effect of TIM-1.Journal of immunology research · 2016Review
- TIM4 Regulates the Anti-Islet Th2 Alloimmune Response.Cell transplantation · 2015Article
- Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2.Cell death and differentiation · 2014Article
- Ubiquitin E3 ligase TNFIAP3 mediates endosome/lysosome fusion in nasal epithelial cells.Molecular and cellular biochemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human being living in constant contact with microbes and pathogen and in the process has developed a recognition pattern of pathogenic structure in the immune cells. The gut lumen has high density of microbes thus the immune response is slightly tolerable to certain microbes, known as commensal flora. These microbes along with other innocuous agents do not cause any inflammation response normally, and are considered as harmless by the immune cells. In immune hypersensitivity condition, such as colitis or food allergy, this mechanism is disturbed. T cell immunoglobulin and mucin domain (TIM)-4 is a phosphatidylserine receptor expressed in mature antigen presenting cells. It is shown that TIM-4 and its ligand TIM-1 are associated in intestinal immune response. However the characteristic of TIM-4 sometimes seems to be two-faced and there is a possibility that TIM-4 also bind to other ligands.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.