ArticleScientific reports2012
Transverse electric field dragging of DNA in a nanochannel.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Piezo-Bio Interaction Interfaces: The Linchpin of Piezoelectric Nanomaterials Toward Biomedicine.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Scaling Behavior of Ionic Conductance Dependent on Surface Charge Inside a Single-Digit Nanopore.Molecules (Basel, Switzerland) · 2025Article
- Effective Modulation of Ion Mobility through Solid-State Single-Digit Nanopores.Nanomaterials (Basel, Switzerland) · 2022Article
- Single DNA Translocation and Electrical Characterization Based on Atomic Force Microscopy and Nanoelectrodes.IEEE open journal of nanotechnology · 2022Article
- Electric control of ionic transport in sub-nm nanopores.RSC advances · 2021Article
- Effect of Electrolyte Concentration on Cell Sensing by Measuring Ionic Current Waveform through Micropores.Biosensors · 2021Article
- Fabrication and Applications of Solid-State Nanopores.Sensors (Basel, Switzerland) · 2019Review
- Generalized Voigt broadening due to thermal fluctuations of electromechanical nanosensors and molecular electronic junctions.The Journal of chemical physics · 2019Article
- Slowing down DNA translocation velocity using a LiCl salt gradient and nanofiber mesh.European biophysics journal : EBJ · 2019Article
- Colloquium: Ionic phenomena in nanoscale pores through 2D materials.Reviews of modern physics · 2019Article
- Transverse dielectrophoretic-based DNA nanoscale confinement.Scientific reports · 2018Article
- Discrimination of three types of homopolymers in single-stranded DNA with solid-state nanopores through external control of the DNA motion.Scientific reports · 2017Article
- Effects of Polymer Length and Salt Concentration on the Transport of ssDNA in Nanofluidic Channels.Biophysical journal · 2017Article
- Tailoring particle translocation via dielectrophoresis in pore channels.Scientific reports · 2016Article
- Decoding DNA, RNA and peptides with quantum tunnelling.Nature nanotechnology · 2016Review
- Theoretical study of the transpore velocity control of single-stranded DNA.International journal of molecular sciences · 2014Article
- Electrically facilitated translocation of protein through solid nanopore.Nanoscale research letters · 2014Article
- Nonequilibrium Ionic Response of Biased Mechanically Controllable Break Junction (MCBJ) Electrodes.The journal of physical chemistry. C, Nanomaterials and interfaces · 2014Article
- Tandem array of nanoelectronic readers embedded coplanar to a fluidic nanochannel for correlated single biopolymer analysis.Biomicrofluidics · 2014Article
- Stretching and controlled motion of single-stranded DNA in locally heated solid-state nanopores.ACS nano · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanopore analysis is an emerging single-molecule strategy for non-optical and high-throughput DNA sequencing, the principle of which is based on identification of each constituent nucleobase by measuring trans-membrane ionic current blockade or transverse tunnelling current as it moves through the pore. A crucial issue for nanopore sequencing is the fact that DNA translocates a nanopore too fast for addressing sequence with a single base resolution. Here we report that a transverse electric field can be used to slow down the translocation. We find 400-fold decrease in the DNA translocation speed by adding a transverse field of 10 mV/nm in a gold-electrode-embedded silicon dioxide channel. The retarded flow allowed us to map the local folding pattern in individual DNA from trans-pore ionic current profiles. This field dragging approach may provide a new way to control the polynucleotide translocation kinetics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.