ArticleInternational journal of clinical and experimental pathology2012
Expressional evaluation of vascular endothelial growth factor (VEGF) protein in urinary bladder carcinoma patients exposed to cigarette smoke.
Article in International journal of clinical and experimental pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
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- Therapeutic effects of axitinib, an anti-angiogenic tyrosine kinase inhibitor, on interstitial cystitis.Scientific reports · 2023Article
- Protective Effects of Thymoquinone, an Active Compound ofMolecules (Basel, Switzerland) · 2021Article
- Significance of Vascular Endothelial Growth Factor Expression in the Bladder Urothelial Carcinoma and Its Association with Tumor Grade and Invasiveness.Iranian journal of pathology · 2021Article
- 6-Gingerol, a Major Ingredient of Ginger AttenuatesMediators of inflammation · 2021Article
- Predictive Markers for Malignant Urothelial Transformation in Balkan Endemic Nephropathy: A Case-Control Study.Cancers · 2020Article
- Thymoquinone, an Active Constituent of Black Seed Attenuates CCl4 Induced Liver Injury in Mice via Modulation of Antioxidant Enzymes, PTEN, P53 and VEGF Protein.Open access Macedonian journal of medical sciences · 2019Article
- Prognostic Significance of Vascular Endothelial Growth Factor (VEGF) and Her-2 Protein in the Genesis of Cervical Carcinoma.Open access Macedonian journal of medical sciences · 2018Article
- Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix.Obstetrics and gynecology international · 2016Article
- Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer.Molecular and clinical oncology · 2015Article
- Psychosocial functioning and vascular endothelial growth factor in patients with head and neck cancer.Head & neck · 2014Article
- Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways.BioMed research international · 2014Review
- Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities.International journal of physiology, pathophysiology and pharmacology · 2014Review
- Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity.International journal of clinical and experimental medicine · 2014Review
- Expressional analysis of p16 and cytokeratin19 protein in the genesis of oral squamous cell carcinoma patients.International journal of clinical and experimental medicine · 2014Article
- Implication of androgen receptor in urinary bladder cancer: a critical mini review.International journal of molecular epidemiology and genetics · 2013Article
- The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy.International journal of clinical and experimental medicine · 2013Article
- In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.Marine drugs · 2012Article
- Clinicopathological significance of PTEN and bcl2 expressions in oral squamous cell carcinoma.International journal of clinical and experimental pathology · 2012Article
- Angiogenesis in upper tract urothelial carcinoma associated with Balkan endemic nephropathy.International journal of clinical and experimental pathology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis is a fundamental process in tumor growth and metastasis. Expression of vascular endothelial growth factor (VEGF) as prognostic indicator has been documented in many types of human tumors. However, the mechanisms responsible for angiogenesis in urinary bladder carcinoma patients are not well defined. Certain carcinogens in tobacco cause DNA damage and may produce specific mutations. In order to investigate the relationship between tobacco smoking, altered patterns of VEGF expression and apoptosis, we have analyzed a group of 125 incident patients with transitional cell carcinoma and 100 cases of control with inflammatory lesions of the bladder. We assessed VEGF overexpression by the use of anti- VEGF antibody through immunohistochemistry, and apoptosis by TUNEL Assay. Expression of VEGF and apoptosis was noticed in 43.2% and 52.8% cases respectively. Both VEGF and apoptosis increased with increasing tumor grade. Apoptosis was seen to be significantly higher in both sexes in the age group of ≥ 50 years (p<0.05) but expression of VEGF was significantly higher among males in the age group of ≥ 50 years (p<0.05). We observed an insignificant association between cigarettes smoking and VEGF overexpression (p>0.05) and significant association with apoptosis. These data support the hypothesis that certain carcinogens derived from cigarette smoking may induce VEGF mutations and apoptosis which in turn are involved in early steps of bladder carcinogenesis.
Indexed as
Identifiers
22558473PMC3341674W1600086213What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.