ArticlePloS one2012
Sortilin participates in light-dependent photoreceptor degeneration in vivo.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina.Investigative ophthalmology & visual science · 2023Article
- Intravitreal Administration of rhNGF Enhances Regenerative Processes in a Zebrafish Model of Retinal Degeneration.Frontiers in pharmacology · 2022Article
- c-Jun N-terminal Kinase Mediates Ligand-independent p75Neuroscience · 2021Article
- SORLA Expression in Synaptic Plexiform Layers of Mouse Retina.Molecular neurobiology · 2020Article
- Effects of the Emitted Light Spectrum of Liquid Crystal Displays on Light-Induced Retinal Photoreceptor Cell Damage.International journal of molecular sciences · 2019Article
- Effects of BNN27, a novel C17-spiroepoxy steroid derivative, on experimental retinal detachment-induced photoreceptor cell death.Scientific reports · 2018Article
- Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light.Experimental eye research · 2017Article
- Polysialylated Neural Cell Adhesion Molecule Protects Against Light-Induced Retinal Degeneration.Investigative ophthalmology & visual science · 2016Article
- Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina.Molecular therapy. Methods & clinical development · 2015Article
- Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light.Scientific reports · 2014Article
- Involvement of NT3 and P75(NTR) in photoreceptor degeneration following selective Müller cell ablation.Journal of neuroinflammation · 2013Article
- Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults.International journal of molecular sciences · 2013Article
- The anti-apoptotic role of neurotensin.Cells · 2013Article
- Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination. ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75(NTR) co-receptor, suggesting that sortilin may participate in the photoreceptor degeneration triggered by intense lighting. We report here that light-exposed albino mice showed sortilin, p75(NTR), and proNGF expression in the outer nuclear layer, the retinal layer where photoreceptor cell bodies are located. In addition, cone progenitor-derived 661W cells subjected to intense illumination expressed sortilin and p75(NTR) and released proNGF into the culture medium. Pharmacological blockade of sortilin with either neurotensin or the "pro" domain of proNGF (pro-peptide) favored the survival of 661W cells subjected to intense light. In vivo, the pro-peptide attenuated retinal cell death in light-exposed albino mice. We propose that an auto/paracrine proapoptotic mechanism based on the interaction of proNGF with the receptor complex p75(NTR)/sortilin participates in intense light-dependent photoreceptor cell death. We therefore propose sortilin as a putative target for intervention in hereditary retinal dystrophies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.