SynthesisPloS one2012
Burden of disease caused by otitis media: systematic review and global estimates.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 472 papers, 17 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biospecimen Procurement for the Study of Head and Neck Disorders
Pneumococcal Carriage and Serotype Distribution in Children With Otitis Media in Malaysia.
Who cites it
472 citing papers in PubMed, 17 syntheses or guidelines pooled it, 1,069 citations in OpenAlex.
- Shorter versus longer antibiotic therapy for children with acute otitis media: A systematic review.European journal of pediatrics · 2026Pooled it
- Systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical antibiotics with steroids for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Aural toilet (ear cleaning) for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Antibiotics versus topical antiseptics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical versus systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical antiseptics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Epidemiology of Chronic Suppurative Otitis Media: Systematic Review To Estimate Global Prevalence.Journal of epidemiology and global health · 2025Pooled it
- Influence of potentially harmful sucking habits on otitis media in children: a systematic review and meta-analysis.Brazilian oral research · 2025Pooled it
- A Systematic Review and Meta-Analysis of the Efficacy of Antimicrobial Chemoprophylaxis for Recurrent Acute Otitis Media in Children.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Pooled it
- Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review.International journal of molecular sciences · 2024Pooled it
- Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents: a systematic review and network meta-analysis of 89 randomized clinical trials.World journal of pediatrics : WJP · 2024Pooled it
- Pooled it
- Antibiotics for acute otitis media in children.The Cochrane database of systematic reviews · 2023Pooled it
- Health-related quality of life after otologic surgical treatment for chronic otitis media: systematic review.Frontiers in neurology · 2023Pooled it
- Systematic review of the efficacy, effectiveness and impact of high-valency pneumococcal conjugate vaccines on otitis media.Human vaccines & immunotherapeutics · 2022Pooled it
- Watchful Waiting Compared With Immediate Antibiotics for Urban Aboriginal and Torres Strait Islander Children With Uncomplicated Acute Otitis Media (WATCH): A Non-Inferiority Randomised Controlled Trial.The Medical journal of Australia · 2026Trial
- Otitis media sequelae and hearing in adolescence after administration of an 11-valent conjugate pneumococcal vaccine in infancy: a prospective cohort study with long-term follow-up of the ARIVAC trial.The Lancet. Child & adolescent health · 2024Trial
- Effects of online social media on improving mothers' behaviors towards preventing their children's otitis media based on the PRECED model: a randomized educational intervention trial.BMC pediatrics · 2023Trial
412 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOtitis media (OM) is a leading cause of health care visits and drugs prescription. Its complications and sequelae are important causes of preventable hearing loss, particularly in developing countries. Within the Global Burden of Diseases, Injuries, and Risk Factors Study, for the year 2005 we estimated the incidence of acute OM, chronic suppurative OM, and related hearing loss and mortality for all ages and the 21 WHO regional areas.
methodsWe identified risk factors, complications and sequelae of OM. We carried out an extensive literature review (Medline, Embase, Lilacs and Wholis) which lead to the selection of 114 papers comprising relevant data. Data were available from 15 of the 21 WHO regions. To estimate incidence and prevalence for all countries we adopted a two stage approach based on risk factors formulas and regression modelling.
resultsAcute OM incidence rate is 10.85% i.e. 709 million cases each year with 51% of these occurring in under-fives. Chronic suppurative OM incidence rate is 4.76 ‰ i.e. 31 million cases, with 22.6% of cases occurring annually in under-fives. OM-related hearing impairment has a prevalence of 30.82 per ten-thousand. Each year 21 thousand people die due to complications of OM.
conclusionsOur study is the first attempt to systematically review the available information and provide global estimates for OM and related conditions. The overall burden deriving from AOM, CSOM and their sequelae is considerable, particularly in the first five years of life and in the poorest countries. The findings call for incorporating OM-focused action within preventive and case management strategies, with emphasis on the more affected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.