ArticlePloS one2012
A novel Escherichia coli O157:H7 clone causing a major hemolytic uremic syndrome outbreak in China.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 78 citations in OpenAlex.
- Available phosphorus and opportunistic pathogens drive geographic variation in Escherichia coli O157:H7 survival in soils across eastern China.Nature food · 2025Article
- Characterization of Seven Shiga Toxin Phages Induced from Human-Derived Shiga Toxin-ProducingMicroorganisms · 2025Article
- Overview of pathogenic Escherichia coli, with a focus on Shiga toxin-producing serotypes, global outbreaks (1982-2024) and food safety criteria.Gut pathogens · 2024Review
- Towards facilitated interpretation of shotgun metagenomics long-read sequencing data analyzed with KMA for the detection of bacterial pathogens and their antimicrobial resistance genes.Frontiers in microbiology · 2024Article
- Characteristics of Shiga Toxin-ProducingToxins · 2023Article
- Adaptive Radioresistance of Enterohemorrhagic Escherichia coli O157:H7 Results in Genomic Loss of Shiga Toxin-Encoding Prophages.Applied and environmental microbiology · 2023Article
- Virulence Factors and Antimicrobial Resistance of UropathogenicBioMed research international · 2023Article
- A Robust One-Step Recombineering System for EnterohemorrhagicMicroorganisms · 2022Article
- ABToxins · 2022Review
- Molecular characterization and phylogeny of Shiga toxin-producingFrontiers in microbiology · 2022Article
- Genotyping Based on CRISPR Loci Diversity and Pathogenic Potential of DiarrheagenicFrontiers in microbiology · 2022Article
- Comparative Pathogenomics ofInfection and immunity · 2021Article
- Review
- Comparative Whole Genome Analysis ofFrontiers in microbiology · 2021Article
- Comparison of Extended-Spectrum Beta-Lactamase-ProducingFrontiers in microbiology · 2021Article
- E. coli diversity: low in colorectal cancer.BMC medical genomics · 2020Article
- Virulence Profiling and Molecular Typing of Shiga Toxin-ProducingMicroorganisms · 2020Article
- Core and Accessory Genome Comparison of Australian and International Strains of O157 Shiga Toxin-ProducingFrontiers in microbiology · 2020Article
- Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.PloS one · 2020Article
- Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem-resistantEmerging microbes & infections · 2020Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An Escherichia coli O157:H7 outbreak in China in 1999 caused 177 deaths due to hemolytic uremic syndrome. Sixteen outbreak associated isolates were found to belong to a new clone, sequence type 96 (ST96), based on multilocus sequence typing of 15 housekeeping genes. Whole genome sequencing of an outbreak isolate, Xuzhou21, showed that the isolate is phylogenetically closely related to the Japan 1996 outbreak isolate Sakai, both of which share the most recent common ancestor with the US outbreak isolate EDL933. The levels of IL-6 and IL-8 of peripheral blood mononuclear cells induced by Xuzhou21 and Sakai were significantly higher than that induced by EDL933. Xuzhou21 also induced a significantly higher level of IL-8 than Sakai while both induced similar levels of IL-6. The expression level of Shiga toxin 2 in Xuzhou21 induced by mitomycin C was 68.6 times of that under non-inducing conditions, twice of that induced in Sakai (32.7 times) and 15 times higher than that induced in EDL933 (4.5 times). Our study shows that ST96 is a novel clone and provided significant new insights into the evolution of virulence of E. coli O157:H7.
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