ArticlePloS one2012
Consent for use of clinical leftover biosample: a survey among Chinese patients and the general public.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Exploring barriers and ethical challenges to medical data sharing: perspectives from Chinese researchers.BMC medical ethics · 2024Article
- Trust and Support for Cancer Research Biobanks: Insights from Cancer Patients in Poland.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Do biobanks need pharmacists? Support of pharmacy students to biobanking of human biological material for pharmaceutical research and development.Frontiers in pharmacology · 2024Article
- Genetic tests as the strongest motivator of cooperation between participants and biobanks-Findings from cross-sectional study.Frontiers in genetics · 2024Article
- Public awareness and attitudes toward biobank and sample donation: A regional Chinese survey.Frontiers in public health · 2022Article
- Public Attitudes to Digital Health Research Repositories: Cross-sectional International Survey.Journal of medical Internet research · 2021Article
- Public Attitudes toward Biobanking of Human Biological Material for Research Purposes: A Literature Review.International journal of environmental research and public health · 2019Review
- Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing.American journal of cancer research · 2018Article
- Th2 axis-related cytokines in patients with neuromyelitis optica spectrum disorders.CNS neuroscience & therapeutics · 2018Article
- Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway.Journal of experimental & clinical cancer research : CR · 2017Article
- Knowledge and Beliefs About Biospecimen Research Among Chinese Older Women in Chicago's Chinatown.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Relevant Information and Informed Consent in Research: In Defense of the Subjective Standard of Disclosure.Science and engineering ethics · 2017Article
- Article
- MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway.Oncotarget · 2015Article
- Demographic differences in willingness to provide broad and narrow consent for biobank research.Biopreservation and biobanking · 2015Article
- The MICHR Genomic DNA BioLibrary: An Empirical Study of the Ethics of Biorepository Development.Journal of empirical research on human research ethics : JERHRE · 2015Article
- Article
- Following the giant's paces-governance issues and bioethical reflections in China.BMC medical ethics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStorage of leftover biosamples generates rich biobanks for future studies, saving time and money and limiting physical impact to sample donors.
objectiveTo investigate the attitudes of Chinese patients and the general public on providing consent for storage and use of leftover biosamples. DESIGN, SETTING AND
participantsCross-sectional surveys were conducted among randomly selected patients admitted to a Shanghai city hospital (n = 648) and members of the general public (n = 492) from May 2010 to July 2010.
main outcome measuresFace-to-face interviews collected respondents-report of their willingness to donate residual biosample, trust in medical institutions, motivation for donation, concerns of donated sample use, expectations for research results return, and so on.
resultsThe response rate was 83.0%. Of the respondents, 89.1% stated that they completely understood or understood most of questions. Willingness to donate residual sample was stated by 64.7%, of which 16.7% desired the option to withdraw their donations anytime afterwards. Only 42.3% of respondents stated they "trust" or "strongly trust" medical institutions, the attitude of trusting or strongly trusting medical institutions were significantly associated with willingness to donate in the general public group.(p<0.05) The overall assent rate for future research without specific consents was also low (12.1%). Hepatitis B virus carriers were significantly less willing than non-carriers to donate biosamples (32.1% vs. 64.7%, p<0.001).
conclusionsLow levels of public trust in medical institutions become serious obstacle for biosample donation and biobanking in China. Efforts to increase public understanding of human medical research and biosample usage and trust in the ethical purposes of biobanking are urgently needed. These efforts will be greatly advanced by the impending legislation on biobanking procedures and intent, and our results may help guide the structure of such law.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.