ArticlePloS one2012
Crystal structure of ChrR--a quinone reductase with the capacity to reduce chromate.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 93 citations in OpenAlex.
- Reduction of Hexavalent Chromium by Stenotrophomonas and Bacillus.MicrobiologyOpen · 2026Review
- A Potent Quinone Reductase Encoded byMolecules (Basel, Switzerland) · 2026Article
- Cloning and expression of chromate reductase from Bacillus paramycoides S48 for chromium remediation.Scientific reports · 2025Article
- Green treatments for polyaromatic hydrocarbons in e-wastes.Biodegradation · 2025Review
- A PadR family transcriptional repressor regulates the transcription of chromate efflux transporter in Enterobacter sp. Z1.Journal of microbiology (Seoul, Korea) · 2024Article
- Phenotypic and resistome analysis of antibiotic and heavy metal resistance in the Antarctic bacterium Pseudomonas sp. AU10.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Draft genome of Raoultella planticola, a high lead resistance bacterium from industrial wastewater.AMB Express · 2023Article
- Article
- Cloning of Nitrate Reductase and Nitrite Reductase Genes and Their Functional Analysis in Regulating Cr(VI) Reduction in Ectomycorrhizal FungusFrontiers in microbiology · 2022Article
- Genome analysis to decipher syntrophy in the bacterial consortium 'SCP' for azo dye degradation.BMC microbiology · 2021Article
- Draft genome sequence data of a chromium reducing bacterium,Data in brief · 2021Article
- NfoR: Chromate Reductase or Flavin Mononucleotide Reductase?Applied and environmental microbiology · 2020Article
- Novel Biochemical Properties and Physiological Role of the Flavin Mononucleotide Oxidoreductase YhdA from Bacillus subtilis.Applied and environmental microbiology · 2020Article
- Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.International journal of environmental research and public health · 2020Review
- Tibet plateau probiotic mitigates chromate toxicity in mice by alleviating oxidative stress in gut microbiota.Communications biology · 2020Article
- Extracellular Vesicle-MediatedMolecular cancer therapeutics · 2020Article
- Not as easy as π: An insertional residue does not explain the π-helix gain-of-function in two-component FMN reductases.Protein science : a publication of the Protein Society · 2019Article
- Identification of the main mechanisms involved in the tolerance and bioremediation of Cr(VI) by Bacillus sp. SFC 500-1E.Environmental science and pollution research international · 2018Article
- Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation.Molecular cancer therapeutics · 2018Article
- Callitriche cophocarpa (water starwort) proteome under chromate stress: evidence for induction of a quinone reductase.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
The Escherichia coli ChrR enzyme is an obligatory two-electron quinone reductase that has many applications, such as in chromate bioremediation. Its crystal structure, solved at 2.2 Å resolution, shows that it belongs to the flavodoxin superfamily in which flavin mononucleotide (FMN) is firmly anchored to the protein. ChrR crystallized as a tetramer, and size exclusion chromatography showed that this is the oligomeric form that catalyzes chromate reduction. Within the tetramer, the dimers interact by a pair of two hydrogen bond networks, each involving Tyr128 and Glu146 of one dimer and Arg125 and Tyr85 of the other; the latter extends to one of the redox FMN cofactors. Changes in each of these amino acids enhanced chromate reductase activity of the enzyme, showing that this network is centrally involved in chromate reduction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.