ArticlePloS one2012
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Pharmacologically enabling the degradation of Na V 1.8 channels to reduce neuropathic pain.Pain · 2025Article
- Review
- CircAMOTL1 RNA and AMOTL1 Protein: Complex Functions ofInternational journal of molecular sciences · 2023Review
- Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis.Frontiers in cell and developmental biology · 2022Review
- NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation.EMBO reports · 2020Article
- The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis.International journal of molecular sciences · 2020Review
- Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers?Cancers · 2020Review
- Yorkie controls tube length and apical barrier integrity during airway development.The Journal of cell biology · 2019Article
- Magi-1 scaffolds NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Review
- Article
- Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions.Nature biotechnology · 2018Article
- The physiological role of Motin family and its dysregulation in tumorigenesis.Journal of translational medicine · 2018Review
- Hippo-YAP/TAZ signaling in angiogenesis.BMB reports · 2018Review
- cAMP response element-binding protein and Yes-associated protein form a feedback loop that promotes neurite outgrowth.Journal of cellular and molecular medicine · 2018Article
- Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins.Cell reports · 2015Article
- Tyrosine phosphorylation of WW proteins.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Article
- The Angiomotins--from discovery to function.FEBS letters · 2014Review
- Defying c-Abl signaling circuits through small allosteric compounds.Frontiers in genetics · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue development and organ growth require constant remodeling of cell-cell contacts formed between epithelial cells. The Hippo signaling cascade curtails organ growth by excluding the transcriptional co-activator Yes Associated Protein 1 (YAP1) from the nucleus. Angiomotin family members recruit YAP1 to tight junctions [1], but whether YAP1 plays a specific role outside of the nucleus is currently unknown. METHODOLOGY/PRINCIPAL
findingsThe present study demonstrates that the E3 ubiquitin ligase Nedd4.2 targets Angiomotin-like 1 (AMOTL1), a family member that promotes the formation of epithelial tight junctions, for ubiquitin-dependent degradation. Unexpectedly, YAP1 antagonizes the function of Nedd4.2, and protects AMOTL1 against Nedd4.2-mediated degradation. YAP1 recruits c-Abl, a tyrosine kinase that binds and phosphorylates Nedd4.2 on tyrosine residues, thereby modifying its ubiquitin-ligase activity. CONCLUSIONS/SIGNIFICANCE: Our results uncover a novel function for cytoplasmic YAP1. YAP1 recruits c-Abl to protect AMOTL1 against Nedd4.2-mediated degradation. Thus, YAP1, excluded from the nucleus, contributes to the maintenance of tight junctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.