ArticlePloS one2012
Why do protein folding rates correlate with metrics of native topology?
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Behavior of Proteins under Pressure from Experimental Pressure-Dependent Structures.The journal of physical chemistry. B · 2021Article
- Effects of Topology and Sequence in Protein Folding Linked via Conformational Fluctuations.Biophysical journal · 2020Article
- How Quickly Do Proteins Fold and Unfold, and What Structural Parameters Correlate with These Values?Biomolecules · 2020Article
- Structural Basis of the Subcellular Topology Landscape ofFrontiers in microbiology · 2019Article
- The response of Greek key proteins to changes in connectivity depends on the nature of their secondary structure.Journal of molecular biology · 2015Article
- Protein unfolding rates correlate as strongly as folding rates with native structure.Protein science : a publication of the Protein Society · 2015Article
- Knotted proteins: A tangled tale of Structural Biology.Computational and structural biotechnology journal · 2015Review
- Effects of knots on protein folding properties.PloS one · 2013Article
- How difficult is it to fold a knotted protein? In silico insights from surface-tethered folding experiments.PloS one · 2012Article
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Authors and funding
4 authors.
Funding
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Abstract
For almost 15 years, the experimental correlation between protein folding rates and the contact order parameter has been under scrutiny. Here, we use a simple simulation model combined with a native-centric interaction potential to investigate the physical roots of this empirical observation. We simulate a large set of circular permutants, thus eliminating dependencies of the folding rate on other protein properties (e.g. stability). We show that the rate-contact order correlation is a consequence of the fact that, in high contact order structures, the contact order of the transition state ensemble closely mirrors the contact order of the native state. This happens because, in these structures, the native topology is represented in the transition state through the formation of a network of tertiary interactions that are distinctively long-ranged.
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