SynthesisPloS one2012
Integrating prevention of mother-to-child HIV transmission programs to improve uptake: a systematic review.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- A systematic review and meta-analysis of vertical transmission route of HIV in Ethiopia.BMC infectious diseases · 2018Pooled it
- Integration of antenatal care services with health programmes in low- and middle-income countries: systematic review.Journal of global health · 2016Pooled it
- A systematic review of interventions to improve prevention of mother-to-child HIV transmission service delivery and promote retention.Journal of the International AIDS Society · 2016Pooled it
- The Uptake of Prevention of Mother-to-Child HIV Transmission Programs in China: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Integrating antiretroviral therapy into antenatal care and maternal and child health settings: a systematic review and meta-analysis.Bulletin of the World Health Organization · 2013Pooled it
- Implementation and Operational Research: Effects of Antenatal Care and HIV Treatment Integration on Elements of the PMTCT Cascade: Results From the SHAIP Cluster-Randomized Controlled Trial in Kenya.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Prevalence and Risk Factors of Pregnancy-Specific Urinary Incontinence: Findings from the Diamater Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Determinants of HIV infection at 18 months of age among HIV-exposed infants in the context of PMTCT interventions in southern Ethiopia.Frontiers in reproductive health · 2024Article
- Understanding Women's Preferences for Prevention of Mother-to-Child HIV Transmission Services in Kenya.International journal of MCH and AIDS · 2024Article
- Integration of HIV care into maternal and child health services in the global IeDEA consortium.Frontiers in global women's health · 2023Article
- Low antiretroviral therapy uptake and low early retention among pregnant women who tested positive for human immunodeficiency virus in informal health centers in urban and semi-rural settings in Cameroon: a prospective cohort study.Frontiers in public health · 2023Article
- Trends and effects of antiretroviral therapy coverage during pregnancy on mother-to-child transmission of HIV in Sub-Saharan Africa. Evidence from panel data analysis.BMC infectious diseases · 2022Article
- Barriers in Implementing the PMTCT in Moretele Sub-District, South Africa: An Exploratory Study.Health services insights · 2022Article
- Prenatal HIV Test Uptake and Its Associated Factors for Prevention of Mother to Child Transmission of HIV in East Africa.International journal of environmental research and public health · 2021Article
- Cardiometabolic Risk Factors in Pregnancy and Implications for Long-Term Health: Identifying the Research Priorities for Low-Resource Settings.Frontiers in cardiovascular medicine · 2020Review
- Achieving development goals for HIV, tuberculosis and malaria in sub-Saharan Africa through integrated antenatal care: barriers and challenges.BMC medicine · 2016Article
- Perceptions and Experiences of Integrated Service Delivery Among Women Living with HIV Attending Reproductive Health Services in Kenya: A Mixed Methods Study.AIDS and behavior · 2016Article
- Bottlenecks and opportunities for delivering integrated pediatric HIV services in Nepal.Current opinion in HIV and AIDS · 2016Article
- Towards elimination of mother-to-child transmission of HIV in Ghana: an analysis of national programme data.International journal for equity in health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe performed a systematic review to assess the effect of integrated perinatal prevention of mother-to-child transmission of HIV interventions compared to non- or partially integrated services on the uptake in low- and middle-income countries.
methodsWe searched for experimental, quasi-experimental and controlled observational studies in any language from 21 databases and grey literature sources.
resultsOut of 28 654 citations retrieved, five studies met our inclusion criteria. A cluster randomized controlled trial reported higher probability of nevirapine uptake at the labor wards implementing HIV testing and structured nevirapine adherence assessment (RRR 1.37, bootstrapped 95% CI, 1.04-1.77). A stepped wedge design study showed marked improvement in antiretroviral therapy (ART) enrolment (44.4% versus 25.3%, p<0.001) and initiation (32.9% versus 14.4%, p<0.001) in integrated care, but the median gestational age of ART initiation (27.1 versus 27.7 weeks, p = 0.4), ART duration (10.8 versus 10.0 weeks, p = 0.3) or 90 days ART retention (87.8% versus 91.3%, p = 0.3) did not differ significantly. A cohort study reported no significant difference either in the ART coverage (55% versus 48% versus 47%, p = 0.29) or eight weeks of ART duration before the delivery (50% versus 42% versus 52%; p = 0.96) between integrated, proximal and distal partially integrated care. Two before and after studies assessed the impact of integration on HIV testing uptake in antenatal care. The first study reported that significantly more women received information on PMTCT (92% versus 77%, p<0.001), were tested (76% versus 62%, p<0.001) and learned their HIV status (66% versus 55%, p<0.001) after integration. The second study also reported significant increase in HIV testing uptake after integration (98.8% versus 52.6%, p<0.001).
conclusionLimited, non-generalizable evidence supports the effectiveness of integrated PMTCT programs. More research measuring coverage and other relevant outcomes is urgently needed to inform the design of services delivering PMTCT programs.
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