ArticlePloS one2012
High genetic diversity among community-associated Staphylococcus aureus in Europe: results from a multicenter study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methicillin-ResistantToxins · 2020Pooled it
- Article
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- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
- Emergence of livestock-associated MRSA in the Egyptian Nile Delta that carry the exfoliative toxin gene etA: a case for enhanced surveillance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Multiple highly resistant clones of MRSA circulating among patients with skin and soft tissue infection, Peshawar, Pakistan 2021-2022.Epidemiology and infection · 2025Article
- The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- Genomic characterization of MRSA recovered from people with cystic fibrosis during two Spanish multicentre studies (2013 and 2021).JAC-antimicrobial resistance · 2024Article
- Whole genome sequencing and pan-genome analysis of Staphylococcus/Mammaliicoccus spp. isolated from diabetic foot ulcers and contralateral healthy skin of Algerian patients.BMC microbiology · 2023Article
- spa Types and Staphylococcal Enterotoxin Production of Staphylococcus aureus Isolated from Wild Boar.Microbial ecology · 2023Article
- Epidemiology of Methicillin-Resistant Staphylococcus aureus in Slovakia, 2020 - Emergence of an Epidemic USA300 Clone in Community and Hospitals.Microbiology spectrum · 2023Article
- Mandatory Notification of Panton-Valentine Leukocidin-Positive Methicillin-ResistantMicroorganisms · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Observational
- Epigenetic and Drug Response Modulation of Epigalocaten-In-3-Gallate inAntibiotics (Basel, Switzerland) · 2023Article
- Whole genome sequencing reveals new links between spa t172/CC59 methicillin-resistant Staphylococcus aureus cases in low-endemicity region of Southwest Finland, 2007‒2016.Scientific reports · 2022Article
- Identification of methicillin-resistantEmerging microbes & infections · 2022Article
- Molecular co-localization of multiple drugs in a nanoscopic delivery vehicle for potential synergistic remediation of multi-drug resistant bacteria.Scientific reports · 2022Article
- Changes in the Genotypic Characteristics of Community-Acquired Methicillin-Resistant Staphylococcus aureus Collected in 244 Medical Facilities in Japan between 2010 and 2018: a Nationwide Surveillance.Microbiology spectrum · 2022Article
- Genomic Insights of FirstInternational journal of molecular sciences · 2022Article
- Drug Resistance and Epigenetic Modulatory Potential of Epigallocatechin-3-Gallate Against Staphylococcus aureus.Current microbiology · 2022Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
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Abstract
backgroundSeveral studies have addressed the epidemiology of community-associated Staphylococcus aureus (CA-SA) in Europe; nonetheless, a comprehensive perspective remains unclear. In this study, we aimed to describe the population structure of CA-SA and to shed light on the origin of methicillin-resistant S. aureus (MRSA) in this continent. METHODS AND
findingsA total of 568 colonization and infection isolates, comprising both MRSA and methicillin-susceptible S. aureus (MSSA), were recovered in 16 European countries, from community and community-onset infections. The genetic background of isolates was characterized by molecular typing techniques (spa typing, pulsed-field gel electrophoresis and multilocus sequence typing) and the presence of PVL and ACME was tested by PCR. MRSA were further characterized by SCCmec typing. We found that 59% of all isolates were associated with community-associated clones. Most MRSA were related with USA300 (ST8-IVa and variants) (40%), followed by the European clone (ST80-IVc and derivatives) (28%) and the Taiwan clone (ST59-IVa and related clonal types) (15%). A total of 83% of MRSA carried Panton-Valentine leukocidin (PVL) and 14% carried the arginine catabolic mobile element (ACME). Surprisingly, we found a high genetic diversity among MRSA clonal types (ST-SCCmec), Simpson's index of diversity = 0.852 (0.788-0.916). Specifically, about half of the isolates carried novel associations between genetic background and SCCmec. Analysis by BURP showed that some CA-MSSA and CA-MRSA isolates were highly related, suggesting a probable local acquisition/loss of SCCmec.
conclusionsOur results imply that CA-MRSA origin, epidemiology and population structure in Europe is very dissimilar from that of USA.
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