ArticlePloS one2012
Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Molecular insights into heart field-specific cardiomyocyte differentiation - A computational study.PloS one · 2026Article
- scBoolSeq: Linking scRNA-seq statistics and Boolean dynamics.PLoS computational biology · 2024Article
- Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation.Frontiers in cell and developmental biology · 2022Article
- Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects.Stem cell research & therapy · 2021Article
- An ECHO of Cartilage:Frontiers in bioengineering and biotechnology · 2021Article
- Determining Relative Dynamic Stability of Cell States Using Boolean Network Model.Scientific reports · 2018Article
- Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2018Review
- Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy.PloS one · 2016Article
- Convergence behaviour and Control in Non-Linear Biological Networks.Scientific reports · 2015Article
- A Semiquantitative Framework for Gene Regulatory Networks: Increasing the Time and Quantitative Resolution of Boolean Networks.PloS one · 2015Article
- Regenerative orthopaedics: in vitro, in vivo...in silico.International orthopaedics · 2014Review
- The skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.