ArticleFrontiers in psychiatry2012
The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys.
Article in Frontiers in psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors.Psychopharmacology · 2025Article
- Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease.Pharmacological research · 2024Review
- Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation.NeuroImage. Clinical · 2019Article
- Serotonergic Neuroplasticity in Alcohol Addiction.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism.ACS chemical neuroscience · 2015Review
- Monkey alcohol tissue research resource: banking tissues for alcohol research.Alcoholism, clinical and experimental research · 2014Article
- Standardized method for the harvest of nonhuman primate tissue optimized for multiple modes of analyses.Cell and tissue banking · 2014Article
- The effects of chronic ethanol self-administration on hippocampal 5-HT1A receptors in monkeys.Drug and alcohol dependence · 2014Article
- Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice.Neuropharmacology · 2014Article
- Chronic alcohol abuse and HIV disease progression: studies with the non-human primate model.Current HIV research · 2014Review
- Neurotoxic saboteurs: straws that break the hippo's (hippocampus) back drive cognitive impairment and Alzheimer's Disease.Neurotoxicity research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Evidence for an interaction between alcohol consumption and the serotonin system has been observed repeatedly in both humans and animal models yet the specific relationship between the two remains unclear. Research has focused primarily on the serotonin transporter (SERT) due in part to its role in regulating extracellular levels of serotonin. The hippocampal formation is heavily innervated by ascending serotonin fibers and is a major component of the neurocircuitry involved in mediating the reinforcing effects of alcohol. The current study investigated the effects of chronic ethanol self-administration on hippocampal SERT in a layer and field specific manner using a monkey model of human alcohol consumption. [(3)H]Citalopram was used to measure hippocampal SERT density in male cynomolgus macaques that voluntarily self-administered ethanol for 18 months. Hippocampal [(3)H]citalopram binding was less dense in ethanol drinkers than in controls, with the greatest effect observed in the molecular layer of the dentate gyrus. SERT density was not correlated with measures of ethanol consumption or blood ethanol concentrations, suggesting the possibility that a threshold level of consumption had been met. The lower hippocampal SERT density observed suggests that chronic ethanol consumption is associated with altered serotonergic modulation of hippocampal neurotransmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.