ArticleFrontiers in psychiatry2012
Neuroanatomical Assessment of the Integrin β3 Mouse Model Related to Autism and the Serotonin System Using High Resolution MRI.
Article in Frontiers in psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2021Pooled it
- Itgb3 expression is developmentally regulated in pyramidal neurons of mouse cortex and hippocampus.Neuroscience letters · 2026Article
- Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition.Nature communications · 2024Article
- Integrin β3 regulates apical dendritic morphology of pyramidal neurons throughout hippocampal CA3.Hippocampus · 2023Article
- Integrin β3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice.BMC neuroscience · 2022Article
- Translational Magnetic Resonance Imaging in Autism Spectrum Disorder From the Mouse Model to Human.Frontiers in neuroscience · 2022Review
- Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development.Molecular autism · 2021Article
- Integrin β3 organizes dendritic complexity of cerebral cortical pyramidal neurons along a tangential gradient.Molecular brain · 2020Article
- Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome.Translational psychiatry · 2020Article
- Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2020Review
- Article
- Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation.Current opinion in neurology · 2018Review
- Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.Molecular autism · 2018Article
- Article
- MicroRNA-Mediated Regulation ofFrontiers in molecular neuroscience · 2017Article
- Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring.Brain and behavior · 2015Article
- Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Quantitative mapping of trimethyltin injury in the rat brain using magnetic resonance histology.Neurotoxicology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrinβ3 (ITGβ3) gene has been associated with both autism and the serotonin system. The purpose of this study was to examine the volumetric differences in the brain of an ITGβ3 homozygous knockout mouse model compared with a corresponding wild-type mouse using high resolution magnetic resonance imaging and detailed statistical analyses. The most striking difference found was an 11% reduction in total brain volume. Moreover, 32 different regions were found to have significantly different relative volumes (percentage total brain volume) in the ITGβ3 mouse. A number of interesting differences relevant to autism were discovered including a smaller corpus callosum volume and bilateral decreases in the hippocampus, striatum, and cerebellum. Relative volume increases were also found in the frontal and parieto-temporal lobes as well as in the amygdala. Particularly intriguing were the changes in the lateral wings of the dorsal raphe nuclei since that nucleus is so integral to the development of many different brain regions and the serotonin system in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.