ArticleFrontiers in physiology2012
Metabolomic applications to decipher gut microbial metabolic influence in health and disease.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 85 citations in OpenAlex.
- Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors.Nutrients · 2018Trial
- Network Pharmacology Combined With Gut Microbiome and Serum Metabolomics Reveals the Therapeutic Mechanisms of Hydroxysafflor Yellow A in Diabetic Kidney Disease.Journal of diabetes research · 2026Article
- Integrated gut microbiota and metabolomics analysis reveals the antitumor effects of ergosta-4,6,8(14),22-tetraen-3-one purified from the medicinal fungus pholiota adiposa in tumor-bearing mice.Frontiers in pharmacology · 2025Article
- Review
- Effects of Milk Replacer-BasedMicrobiology spectrum · 2022Article
- A Targeted Serum Metabolomics GC-MS Approach Identifies Predictive Blood Biomarkers for Retained Placenta in Holstein Dairy Cows.Metabolites · 2021Article
- A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes.Saudi journal of biological sciences · 2021Article
- Mitochondrial DNA haplogroup M7 confers a reduced risk of colorectal cancer in a Han population from northern China.Journal of cellular and molecular medicine · 2021Article
- Colorectal Cancer Stage-Specific Fecal Bacterial Community Fingerprinting of the Taiwanese Population and Underpinning of Potential Taxonomic Biomarkers.Microorganisms · 2021Article
- Gut microbiota composition and metabolomic profiles of wild and captive Chinese monals (Lophophorus lhuysii).Frontiers in zoology · 2020Article
- Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches.Metabolites · 2020Review
- Serum metabolomics identifies metabolite panels that differentiate lame dairy cows from healthy ones.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Dietary Patterns Are Associated with Serum Metabolite Patterns and Their Association Is Influenced by Gut Bacteria among Older German Adults.The Journal of nutrition · 2020Article
- Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome.World journal of gastroenterology · 2018Article
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome.Microbiome · 2017Article
- The Opportunities of Metabolomics in Drug Safety Evaluation.Current pharmacology reports · 2017Article
- Transcriptomics-driven lipidomics (TDL) identifies the microbiome-regulated targets of ileal lipid metabolism.NPJ systems biology and applications · 2017Article
- Global Fecal and Plasma Metabolic Dynamics Related toFrontiers in microbiology · 2017Article
- Comparing metabolite profiles of habitual diet in serum and urine.The American journal of clinical nutrition · 2016Article
- Urinary Metabolic Phenotyping Reveals Differences in the Metabolic Status of Healthy and Inflammatory Bowel Disease (IBD) Children in Relation to Growth and Disease Activity.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary preferences and nutrients composition have been shown to influence human and gut microbial metabolism, which ultimately has specific effects on health and diseases' risk. Increasingly, results from molecular biology and microbiology demonstrate the key role of the gut microbiota metabolic interface to the overall mammalian host's health status. There is therefore raising interest in nutrition research to characterize the molecular foundations of the gut microbial-mammalian cross talk at both physiological and biochemical pathway levels. Tackling these challenges can be achieved through systems biology approaches, such as metabolomics, to underpin the highly complex metabolic exchanges between diverse biological compartments, including organs, systemic biofluids, and microbial symbionts. By the development of specific biomarkers for prediction of health and disease, metabolomics is increasingly used in clinical applications as regard to disease etiology, diagnostic stratification, and potentially mechanism of action of therapeutical and nutraceutical solutions. Surprisingly, an increasing number of metabolomics investigations in pre-clinical and clinical studies based on proton nuclear magnetic resonance ((1)H NMR) spectroscopy and mass spectrometry provided compelling evidence that system wide and organ-specific biochemical processes are under the influence of gut microbial metabolism. This review aims at describing recent applications of metabolomics in clinical fields where main objective is to discern the biochemical mechanisms under the influence of the gut microbiota, with insight into gastrointestinal health and diseases diagnostics and improvement of homeostasis metabolic regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.