ArticleFrontiers in physiology2012
Sympathetic responses to central hypovolemia: new insights from microneurographic recordings.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heart rate variability as a dual-use digital biomarker: integrating clinical, AI, and operational perspectives on human performance and resilience.BMC cardiovascular disorders · 2026Pooled it
- Trial
- Shock Induced Endotheliopathy and High Trauma Mortality-Fight-or-Flight Response Revisited.International journal of molecular sciences · 2026Review
- Pulse Rate Variability Analysis During Hemorrhage in an Experimental Porcine Model.Medical research archives · 2025Article
- Are crystalloid-based fluid expansion strategies still relevant in the first hours of trauma induced hemorrhagic shock?Critical care (London, England) · 2024Review
- Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals.The journal of physiological sciences : JPS · 2024Article
- Development and evaluation of a wearable peripheral vascular compensation sensor in a swine model of hemorrhage.Biomedical optics express · 2023Article
- Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy.Cardiovascular research · 2023Review
- Enteral gabexate mesilate improves volume requirements and autonomic cardiovascular function after experimental trauma/hemorrhagic shock in the absence of blood reperfusion.American journal of translational research · 2022Article
- Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction.Physiological reports · 2019Article
- Blood pressure variability, heart functionality, and left ventricular tissue alterations in a protocol of severe hemorrhagic shock and resuscitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- The pathophysiology of the vasovagal response.Heart rhythm · 2018Review
- Modeling Arterial Pulse Pressure From Heart Rate During Sympathetic Activation by Progressive Central Hypovolemia.Frontiers in physiology · 2018Article
- Anesthesia-Associated Relative Hypovolemia: Mechanisms, Monitoring, and Treatment Considerations.Frontiers in veterinary science · 2018Article
- The Role of Failing Autonomic Nervous System on Life-Threatening Idiopathic Systemic Capillary Leak Syndrome.Frontiers in medicine · 2018Article
- The physiology of blood loss and shock: New insights from a human laboratory model of hemorrhage.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Support Vector Machine Based Monitoring of Cardio-Cerebrovascular Reserve during Simulated Hemorrhage.Frontiers in physiology · 2017Article
- Passive Heating Attenuates Post-exercise Cardiac Autonomic Recovery in Healthy Young Males.Frontiers in neuroscience · 2017Article
- Non-linear Heart Rate and Blood Pressure Interaction in Response to Lower-Body Negative Pressure.Frontiers in physiology · 2017Article
- Cardiovascular Response Patterns to Sympathetic Stimulation by Central Hypovolemia.Frontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemorrhage remains a major cause of mortality following traumatic injury in both military and civilian settings. Lower body negative pressure (LBNP) has been used as an experimental model to study the compensatory phase of hemorrhage in conscious humans, as it elicits central hypovolemia like that induced by hemorrhage. One physiological compensatory mechanism that changes during the course of central hypovolemia induced by both LBNP and hemorrhage is a baroreflex-mediated increase in muscle sympathetic nerve activity (MSNA), as assessed with microneurography. The purpose of this review is to describe recent results obtained using microneurography in our laboratory as well as those of others that have revealed new insights into mechanisms underlying compensatory increases in MSNA during progressive reductions in central blood volume and how MSNA is altered at the point of hemodynamic decompensation. We will also review recent work that has compared direct MSNA recordings with non-invasive surrogates of MSNA to determine the appropriateness of using such surrogates in assessing the clinical status of hemorrhaging patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.