ArticleJournal of cutaneous and aesthetic surgery2012
Giant epithelial malignancies (Basal cell carcinoma, squamous cell carcinoma): a series of 20 tumors from a single center.
Article in Journal of cutaneous and aesthetic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas.Life (Basel, Switzerland) · 2024Article
- A lobulated mass on the upper back with prominent vasculature: A giant basal cell carcinoma.Dermatology reports · 2021Article
- Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review.Frontiers in oncology · 2021Review
- [Photodynamic therapy of a giant basal cell carcinoma in a 71-year-old woman].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020Article
- Multidisciplinary management of giant cervicothoracic cutaneous squamous cell carcinoma.International journal of surgery case reports · 2019Article
- Ulcerating Lichen Planopilaris - Successful Treatment by Surgery.Open access Macedonian journal of medical sciences · 2018Article
- Ulcerated Metatypical Basal Cell Carcinoma of the Forehead.Open access Macedonian journal of medical sciences · 2017Article
- Scalping Surgery - Dermatologic Indications beyond Curative Primary Skin Cancer Surgery.Open access Macedonian journal of medical sciences · 2017Article
- Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion.Open access Macedonian journal of medical sciences · 2017Article
- A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature.Journal of medical case reports · 2017Review
- Myiasis on a Giant Squamous Cell Carcinoma of the Scalp: A Case Report and Review of Relevant Literature.World journal of oncology · 2016Article
- Giant cutaneous squamous cell carcinoma requiring emergent embolization.JAAD case reports · 2016Article
- Extensive Squamous Cell Carcinoma Originating from a Burn Scar: Marjolin's Ulcer with an Unusual Presentation.Annals of dermatology · 2016Article
- Relapsing advanced metatypical basal cell carcinomas (MTBCC) of the face: surgical modalities.Wiener medizinische Wochenschrift (1946) · 2014Article
- Metatypical Basal cell carcinomas: a successful surgical approach to two cases with different tumor locations.Maedica · 2014Article
- Advanced basal cell carcinoma.Wiener medizinische Wochenschrift (1946) · 2013Review
- Giant-neglected facial Marjolin's ulcer associated with perioperative blood loss anemia.Avicenna journal of medicineArticle
Corrections and comments
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong nonmelanoma skin cancer (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common. Giant NMSCs have occasionally reported in the medical literature with particular problems related to diagnosis and treatment. The aim of this study was to analyze patients, treatment, and outcome with giant BCC/SCC. MATERIALS AND
methodsWe analyzed our files between January 1, 2008, and December 31, 2011, of an academic teaching hospital in the dermatology department. Patients were analyzed according to demographic factors, clinical presentation, histopathology, treatment, and outcome. American Society of Anesthesiology physical status system was used to assess the fitness of patients before surgery.
resultsThe frequency of giant NMSC was estimated as 0.4% for both tumor entities. 80% of giant BCC patients were female and 100% of giant SCC patients were male. The mean age was 81.5 ± 8.5 years for BCC) and 79.5 ± 11.4 years for SCC. The major anatomical site was the scalp. Four of 10 BCCs were classified metatypic (basosquamous). Perineural infiltration was seen in 5 NMSCs. Seventy percent of patients had an ASA score ≥3. Surgery was performed in general anaesthesia in 5 (BCC) and 6 (SCC) patients, respectively. All other patients were operated in local or tumescence anesthesia. Blood transfusions were necessary in five patients. The primary treatment was delayed Mohs technique. Defect closure was realized with rotational flaps in most cases. Neoadjuvant chemoimmune therapy and adjuvant combined cetuximab/radiotherapy have been performed in three patients. We observed three deaths, all unrelated to NMSC. 75% of patients achieved complete remission.
conclusionsGiant NMSC is uncommon but not rare. These tumors are high-risk subtypes. Treatment needs an interdisciplinary approach.
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