ArticleHuman molecular genetics2012
A non-human primate system for large-scale genetic studies of complex traits.
Article in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Mosaic patterns of selection in genomic regions associated with diverse human traits.PLoS genetics · 2022Article
- Evaluation of the Dose-Dependent Inflammatory Response and No-Observable Adverse Effect Level of Intravitreal Endotoxin in the African Green Monkey.Translational vision science & technology · 2022Article
- Epigenetic clock and methylation studies in vervet monkeys.GeroScience · 2022Article
- Neurodegenerative disease biomarkers AβBrain and behavior · 2018Article
- Pair housing of Vervets/African Green Monkeys for biomedical research.American journal of primatology · 2017Article
- Vitamin D heritability and effect of pregnancy status in Vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation.American journal of physical anthropology · 2016Article
- The genome of the vervet (Chlorocebus aethiops sabaeus).Genome research · 2015Article
- Population Bottlenecks and Pathogen Extinction: "Make This Everyone's Mission to Mars, Including Yours".Journal of virology · 2015Article
- Local Virus Extinctions following a Host Population Bottleneck.Journal of virology · 2015Article
- Hematology and Clinical Chemistry Measures During and After Pregnancy and Age- and Sex-Specific Reference Intervals in African Green Monkeys (Chlorocebus aethiops sabaeus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits.BMC biology · 2015Article
- Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain.PloS one · 2015Article
- Dissecting impulsivity and its relationships to drug addictions.Annals of the New York Academy of Sciences · 2014Review
- The neutralizing capacity of antibodies elicited by parainfluenza virus infection of African Green Monkeys is dependent on complement.Virology · 2014Article
- Comparative primate genomics: emerging patterns of genome content and dynamics.Nature reviews. Genetics · 2014Review
- A method for estimating the effective number of loci affecting a quantitative character.Theoretical population biology · 2013Article
- Development of amyloid burden in African Green monkeys.Neurobiology of aging · 2013Article
- Effects of a Western-type diet on plasma lipids and other cardiometabolic risk factors in African green monkeys (Chlorocebus aethiops sabaeus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- Systems biology of the vervet monkey.ILAR journal · 2013Review
- Nonhuman primate models in the genomic era: a paradigm shift.ILAR journal · 2013Review
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
Abstract
Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (Chlorocebus aethiops sabaeus) are genetically homogeneous and large enough to permit well-powered genetic mapping studies of quantitative traits relevant to human health, including expression quantitative trait loci (eQTL). Previous transcriptome-wide investigation in an extended vervet pedigree identified 29 heritable transcripts for which levels of expression in peripheral blood correlate strongly with expression levels in the brain. Quantitative trait linkage analysis using 261 microsatellite markers identified significant (n = 8) and suggestive (n = 4) linkages for 12 of these transcripts, including both cis- and trans-eQTL. Seven transcripts, located on different chromosomes, showed maximum linkage to markers in a single region of vervet chromosome 9; this observation suggests the possibility of a master trans-regulator locus in this region. For one cis-eQTL (at B3GALTL, beta-1,3-glucosyltransferase), we conducted follow-up single nucleotide polymorphism genotyping and fine-scale association analysis in a sample of unrelated Caribbean vervets, localizing this eQTL to a region of <200 kb. These results suggest the value of pedigree and population samples of the Caribbean vervet for linkage and association mapping studies of quantitative traits. The imminent whole genome sequencing of many of these vervet samples will enhance the power of such investigations by providing a comprehensive catalog of genetic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.