ArticleCirculation research2012
Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.
Article in Circulation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- A Universal Plasticizer Alkylsulfonic Phenyl Ester Activates Pregnane X Receptor to Increase Intestinal Cholesterol Uptake.International journal of molecular sciences · 2026Article
- Study on biomarkers of homocysteine-induced transformation of vascular smooth muscle cells into foam cells.Scientific reports · 2026Article
- Review
- Comprehensive Analysis of 1-Year-Old Female Apolipoprotein E-Deficient Mice Reveals Advanced Atherosclerosis with Vulnerable Plaque Characteristics.International journal of molecular sciences · 2024Article
- Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor.Frontiers in endocrinology · 2024Article
- Trimethylamine increases intestinal fatty acid absorption:Journal of nutritional science · 2023Article
- ATP-Binding Cassette Protein ABCC10 Deficiency Prevents Diet-Induced Obesity but Not Atherosclerosis in Mice.International journal of molecular sciences · 2022Article
- Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding.Science advances · 2022Article
- Review
- Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages.Journal of cellular and molecular medicine · 2019Article
- microRNA-30c reduces plasma cholesterol in homozygous familial hypercholesterolemic and type 2 diabetic mouse models.Journal of lipid research · 2018Article
- Batf3-dependent CD8αEBioMedicine · 2017Article
- MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice.The Journal of biological chemistry · 2016Article
- Pre-germinated brown rice prevented high fat diet induced hyperlipidemia through ameliorating lipid synthesis and metabolism in C57BL/6J mice.Journal of clinical biochemistry and nutrition · 2016Article
- Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies.Environmental disease · 2016Article
- Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis.Journal of lipid research · 2015Article
- Impaired cholesterol metabolism and enhanced atherosclerosis in clock mutant mice.Circulation · 2013Article
- Regulating intestinal function to reduce atherogenic lipoproteins.Clinical lipidology · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
rationaleHigh fasting serum lipid levels are significant risk factors for atherosclerosis. However, the contributions of postprandial excursions in serum lipoproteins to atherogenesis are less well-characterized.
objectiveThis study aims to delineate whether changes in intestinal lipid absorption associated with loss of inositol-requiring enzyme 1β (Ire1β) would affect the development of hyperlipidemia and atherosclerosis in Apoe(-/-) mice. METHODS AND
resultsWe used Ire1β-deficient mice to assess the contribution of intestinal lipid absorption to atherosclerosis. Here, we show that Ire1b(-/-)/Apoe(-/-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more lipids, exhibit hyperlipidemia, and have higher levels of atherosclerotic plaques compared with Apoe(-/-) mice when fed chow and western diets.
conclusionsThese studies indicate that Ire1β regulates intestinal lipid absorption and that increased intestinal lipoprotein production contributes to atherosclerosis.
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Registered trials
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