ArticleProceedings of the National Academy of Sciences of the United States of America2012
Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 46 citations in OpenAlex.
- A mosquito-inspired theoretical framework for acoustic signal detection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- Hearing as adaptive cascaded envelope interpolation.Communications biology · 2023Article
- Rod-cone signal interference in the retina shapes perception in primates.Frontiers in ophthalmology · 2023Article
- Complex dynamics of hair bundle of auditory nervous system (II): forced oscillations related to two cases of steady state.Cognitive neurodynamics · 2022Article
- Complex dynamics of hair bundle of auditory nervous system (I): spontaneous oscillations and two cases of steady states.Cognitive neurodynamics · 2022Article
- Two-tone distortion in reticular lamina vibration of the living cochlea.Communications biology · 2020Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.Trends in neurosciences · 2019Review
- A novel signal processing approach to auditory phantom perception.Psychonomic bulletin & review · 2019Article
- A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ.Nature communications · 2018Article
- Frequency doubling by activeRoyal Society open science · 2018Article
- Control of a hair bundle's mechanosensory function by its mechanical load.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Active amplification in insect ears: mechanics, models and molecules.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- All that jazz coming out of my ears.Biophysical journal · 2014Article
- A tympanal insect ear exploits a critical oscillator for active amplification and tuning.Current biology : CB · 2013Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Processing of two-tone stimuli by the auditory system introduces prominent masking of one frequency component by the other as well as additional "phantom" tones that are absent in the sound input. Mechanical correlates of these psychophysical phenomena have been observed in sound-evoked mechanical vibrations of the mammalian cochlea and are thought to originate in sensory hair cells from the intrinsic nonlinearity associated with mechano-electrical transduction by ion channels. However, nonlinearity of the transducer is not sufficient to explain the rich phenomenology of two-tone interferences in hearing. Here we show that active oscillatory movements of single hair-cell bundles elicit two-tone suppression and distortions that are shaped by nonlinear amplification of periodic stimuli near the characteristic frequency of spontaneous oscillations. When both stimulus frequencies enter the bandwidth of the hair-bundle amplifier, two-tone interferences display level functions that are characteristic both of human psychoacoustics and of in vivo mechanical measurements in auditory organs. Our work distinguishes the frequency-dependent nonlinearity that emerges from the active process that drives the hair bundle into spontaneous oscillations from the passive nonlinear compliance associated with the direct gating of transduction channels by mechanical force. Numerical simulations based on a generic description of an active dynamical system poised near an oscillatory instability--a Hopf bifurcation--account quantitatively for our experimental observations. In return, we conclude that the properties of two-tone interferences in hearing betray the workings of self-sustained "critical" oscillators, which function as nonlinear amplifying elements in the inner ear.
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