ArticleBlood2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Modulation of senescent LeprStem cell research & therapy · 2025Article
- Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases.International journal of molecular sciences · 2023Review
- The potential role of the thymus in immunotherapies for acute myeloid leukemia.Frontiers in immunology · 2023Review
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- Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions.Aging and disease · 2022Article
- On the Role of Paraoxonase-1 and Chemokine Ligand 2 (C-C motif) in Metabolic Alterations Linked to Inflammation and Disease. A 2021 Update.Biomolecules · 2021Review
- Acute Myeloid Leukemia: Is It T Time?Cancers · 2021Review
- AIRE deficiency, from preclinical models to human APECED disease.Disease models & mechanisms · 2021Review
- Article
- Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration.Annals of the rheumatic diseases · 2020Article
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- Cells exhibiting strongProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cellular and epigenetic drivers of stem cell ageing.Nature reviews. Molecular cell biology · 2018Review
- DNA methylation-based biomarkers and the epigenetic clock theory of ageing.Nature reviews. Genetics · 2018Review
- Senescence in Health and Disease.Cell · 2017Review
- Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling.Physiological reports · 2017Article
- Restoration of Thymus Function with Bioengineered Thymus Organoids.Current stem cell reports · 2016Article
- Forging a signature of in vivo senescence.Nature reviews. Cancer · 2015Review
- A Tale from TGF-β Superfamily for Thymus Ontogeny and Function.Frontiers in immunology · 2015Review
- The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2).PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Involution of the thymus results in reduced production of naive T cells, and this in turn is thought to contribute to impaired immunity in the elderly. Early T-cell progenitors (ETPs), the most immature intrathymic T-cell precursors, harvested from the involuted thymus exhibit a diminished proliferative potential and increased rate of apoptosis and as a result their number is significantly reduced. In the present study, we show that these age-induced alterations result in part from increased expression of the Ink4a tumor-suppressor gene in ETPs. We also show that repression of Ink4a in aged ETPs results in their partial rejuvenation and that this can be accomplished by in vivo fibroblast growth factor 7 administration. These results define a genetic basis for thymocyte progenitor aging and demonstrate that the senescence-associated gene Ink4a can be pharmacologically repressed in ETPs to partially reverse the effects of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.