ArticleMolecular and cellular biochemistry2012
Effect of hepcidin on intracellular calcium in human osteoblasts.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Calcium's Role and Signaling in Aging Muscle, Cellular Senescence, and Mineral Interactions.International journal of molecular sciences · 2023Review
- Role of Iron Accumulation in Osteoporosis and the Underlying Mechanisms.Current medical science · 2023Article
- Pentosan polysulfate regulates hepcidin 1-facilitated formation and function of osteoclast derived from canine bone marrow.PloS one · 2022Article
- Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells.PloS one · 2021Article
- New highlight in breast cancer development: the key role of hepcidin and iron metabolism.Annals of translational medicine · 2018Article
- Modulation of iron metabolism by iron chelation regulates intracellular calcium and increases sensitivity to doxorubicin.Bosnian journal of basic medical sciences · 2016Article
- Reducing iron accumulation: A potential approach for the prevention and treatment of postmenopausal osteoporosis.Experimental and therapeutic medicine · 2015Article
- Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration.Inflammation · 2015Article
- Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen-activated protein kinase/P38 signaling pathways in mesenchymal stem cells.Molecular medicine reports · 2015Article
- The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis.Frontiers in aging neuroscience · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepcidin is known to increase intracellular iron through binding to and degrading ferroportin, which is a transmembrane protein that transports iron from the intracellular to the outside. However, it is not clear whether hepcidin has a similar effect on intracellular calcium. Here, we investigated the influence of hepcidin on intracellular calcium in human osteoblasts, with or without high environmental iron concentrations. Our data showed that hepcidin (<100 nmol/L) could increase intracellular calcium, and this effect was more significant when cells were exposed to high environmental iron concentrations. To further explore its underlying mechanisms, we pretreated human osteoblasts with Nimodipine, a L-type calcium channel blocker, and Dantrolene, a ryanodine receptor antagonist to inhibit abnormal calcium release from the sarco-endoplasmic reticulum. These treatments had not resulted in any alteration of intracellular calcium in human osteoblasts. Thus, these findings indicate that the increase of intracellular calcium induced by hepcidin is probably due to calcium release from endoplasmic reticulum, which is triggered by calcium influx.
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Registered trials
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