ArticleThe journal of nutrition, health & aging2012
Ghrelin and leptin secretion in patients with moderate Alzheimer's disease.
Article in The journal of nutrition, health & aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.International journal of molecular sciences · 2025Review
- The Crosstalk Between Amyloid-β, Retina, and Sleep for the Early Diagnosis of Alzheimer's Disease: A Narrative Review.Journal of Alzheimer's disease reports · 2024Review
- Ghrelin system in Alzheimer's disease.Current opinion in neurobiology · 2023Review
- Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages.European journal of histochemistry : EJH · 2022Article
- Plasma Leptin Reflects Progression of Neurofibrillary Pathology in Animal Model of Tauopathy.Cellular and molecular neurobiology · 2022Article
- Understanding the Physiological Links Between Physical Frailty and Cognitive Decline.Aging and disease · 2020Review
- The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease.Frontiers in neuroscience · 2020Review
- Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease.Frontiers in neuroscience · 2020Review
- U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults.Nutrients · 2019Article
- SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model.Molecular neurobiology · 2018Article
- The Relation of Circulating Levels of Leptin with Cognition in Patients with Alzheimer's Disease.Noro psikiyatri arsivi · 2018Article
- MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease.International journal of molecular sciences · 2018Article
- Increased Serum Acylated Ghrelin Levels in Patients with Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2018Article
- Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies.Journal of psychopharmacology (Oxford, England) · 2017Review
- Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia.Biogerontology · 2017Article
- Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels.Scientific reports · 2017Article
- Ghrelin and Neurodegenerative Disorders-a Review.Molecular neurobiology · 2017Review
- Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson's Disease.Frontiers in aging neuroscience · 2016Review
- Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Cognitive aspects of frailty: mechanisms behind the link between frailty and cognitive impairment.The journal of nutrition, health & aging · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight loss is a characteristic finding of patients with Alzheimer's disease (AD). It seems that precedes cognitive impairment by some years, but the underlying causes are not fully understood. Ghrelin and leptin are involved in energy homeostasis, and may be implicated in weight losing observed in these patients.
objectiveTo examine the potential relationship between ghrelin and leptin levels and weight loss in patients with AD.
designThe study included 27 patients (10 men and 17 women) with AD of moderate severity, and 23 controls (10 males and 13 females), matched for age and BMI. Body fat and lean mass content were assessed using a portable apparatus. Cognitive function was assessed with the Mini-Mental State Examination. Basal serum samples for the measurement of leptin, ghrelin, insulin and glucose were obtained, and serum ghrelin, insulin and glucose were measured after a 75-gr glucose load in both groups.
resultsPatients with Alzheimer Disease (AD) have lower lean mass content compared to controls. Basal ghrelin and leptin is similar in patients with AD and controls. The area-under-the-curve for ghrelin (AUC) is lower in male patients with AD compared to control males, while no difference was observed between females AD and controls.
conclusionMale patients with AD, in contrast with female patients, fail to maintain a normal energy homeostasis even in the early stages of the disease, as shown by the decreased lean mass content in males AD compared to controls. Disruption of the normal compensatory modulation of ghrelin secretion might contribute to the metabolic changes observed in male patients with AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.