ArticleThe journal of nutrition, health & aging2012
Serum high-density lipoprotein cholesterol levels correlate well with functional but not with cognitive status in 85-year-old subjects.
Article in The journal of nutrition, health & aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study.BMC geriatrics · 2018Trial
- Very high high-density lipoprotein cholesterol may be associated with higher risk of cognitive impairment in older adults.Nutrition journal · 2024Article
- A Novel Frailty Score Based on Laboratory Parameters (FIMS Score) for the Management of Older Patients with Severe Aortic Stenosis.Journal of clinical medicine · 2023Article
- The identification and prediction of frailty based on Bayesian network analysis in a community-dwelling older population.BMC geriatrics · 2022Article
- Potential Value of Serum Lipid in the Identication of Postoperative Delirium Undergoing Knee/Hip Arthroplasty: The Perioperative Neurocognitive Disorder and Biomarker Lifestyle Study.Frontiers in psychiatry · 2022Article
- Review
- The role of lipoprotein profile in depression and cognitive performance: a network analysis.Scientific reports · 2020Article
- Evidence of functional declining and global comorbidity measured at baseline proved to be the strongest predictors for long-term death in elderly community residents aged 85 years: a 5-year follow-up evaluation, the OCTABAIX study.Clinical interventions in aging · 2016Article
- Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe evaluate the association between high-density lipoprotein cholesterol (HDL-C) levels and physical and cognitive performance indicators in 85-year-old subjects.
designProspective cohort study.
settingA community-based study.
participants321 subjects enrolled in the Octabaix Study.
methodsFunctional status was determined using the Lawton-Brody Index (LI) and the Barthel Index (BI). Cognition was assessed using the modified Spanish version of the Mini-Mental State Examination (MEC). We also measured risks related to nutrition and falls, as well as comorbidity and chronic drug prescription. HDL-C serum concentrations <40 mg/dl for men and <46 mg/dl for women were used as cut-off values to discriminate between normal and low HDL-C concentrations.
resultsThe sample consisted of 197 women (61%) and 124 men. Mean HDL-C levels were 56.5 ± 15 mg/dl, with gender differences being found (59.3 ± 15 mg/dl in women vs. 52.1 ± 13 mg/dl in men; p<0.0001). Sixty-one subjects (19%) had low HDL-C values. HDL-C levels correlated with BI (r=0.11, p=0.04) and LI (r=0.17, p=0.002) scores, but not with MEC scores (r=0.08, p=0.13). Poor BI and LI scores, lower MEC scores, a risk of falls and malnutrition, and polypharmacy were all associated with lower HDL-C values in the bivariate analysis. Multiple logistic regression analysis showed only a significant association between normal HDL-C serum values and better BI scores (p<0.001, OR 1.02, 95% CI 1.01-1.04).
conclusionsIndividuals with higher levels of HDL-C had better functional and cognitive status, but after multivariate analysis this relationship only remained significant for functional status.
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