ArticleDepression and anxiety2012
Maternal depression and prenatal exposure to methamphetamine: neurodevelopmental findings from the infant development, environment, and lifestyle (ideal) study.
Article in Depression and anxiety, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Prenatal Methamphetamine Exposure: Effects on Child Development–A Systematic Review.Deutsches Arzteblatt international · 2021Pooled it
- Maternal perinatal depression and infant self-regulation: A meta-analytic review.Development and psychopathology · 2025Review
- A Perinatal Review of Prevalence and Risk Factors for Substance Abuse Among Pregnant Women in Singapore.Cureus · 2025Article
- Daily, limited access to methamphetamine self-administration during pregnancy leads to increased methamphetamine sensitivity in adult offspring.Developmental psychobiology · 2023Article
- Neonatal Intensive Care Unit Network Neurobehavioral Scale Profiles in Full-Term Infants: Associations with Maternal Adversity, Medical Risk, and Neonatal Outcomes.The Journal of pediatrics · 2022Observational
- PROTOCOL: Psychosocial, pharmacological and legal interventions for improving the psychosocial outcomes of children with substance misusing parents.Campbell systematic reviews · 2020Article
- Stimulant Use in Pregnancy: An Under-recognized Epidemic Among Pregnant Women.Clinical obstetrics and gynecology · 2019Review
- Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat.Drug and alcohol dependence · 2017Article
- Regions of variable DNA methylation in human placenta associated with newborn neurobehavior.Epigenetics · 2016Article
- The cortisol level and its relationship with depression, stress and anxiety indices in chronic methamphetamine-dependent patients and normal individuals undergoing inguinal hernia surgery.Medical journal of the Islamic Republic of Iran · 2016Article
- Methamphetamine and the hypothalamic-pituitary-adrenal axis.Frontiers in neuroscience · 2015Review
- Developmental and behavioral consequences of prenatal methamphetamine exposure: A review of the Infant Development, Environment, and Lifestyle (IDEAL) study.Neurotoxicology and teratologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundMaternal depression is associated with a higher incidence of behavioral problems in infants, but the effects of maternal depression as early as 1 month are not well characterized. The objective of this study is to determine the neurobehavioral effects of maternal depression on infants exposed and not exposed to methamphetamine (MA) using the NICU Network Neurobehavioral Scale (NNNS).
methodsFour hundred twelve mother-infant pairs were enrolled (MA = 204) and only biological mothers with custody of their child were included in the current analysis. At the 1-month visit (n = 126 MA-exposed; n = 193 MA-unexposed), the Beck Depression Inventory-II (BDI-II) was administered, and the NNNS was administered to the infant. Exposure was identified by self-report and/or gas chromatography/mass spectroscopy confirmation of amphetamine and metabolites in newborn meconium. Unexposed subjects were matched, denied amphetamine use, and had negative meconium screens. General Linear Models tested the effects of maternal depression and prenatal MA exposure on NNNS, with significance accepted at P < .05.
resultsThe MA group had an increased incidence of depression-positive diagnosis and increased depression scores on the BDI-II. After adjusting for covariates, MA exposure was associated with increased arousal and handling scores, and a decreased ability to self-regulate. Maternal depression was associated with higher autonomic stress and poorer quality of movement. No additional differences were observed in infants whose mothers were both depressed and used MA during pregnancy.
conclusionsMaternal depression is associated with neurodevelopmental patterns of increased stress and decreased quality of movement, suggesting maternal depression influences neurodevelopment in infants as young as 1 month.
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Registered trials
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