Evidence map›Paper›PMID 22555656›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2012

Knowledge integration at the center of genomic medicine.

Muin J Khoury, Marta Gwinn, W David Dotson, Sheri D Schully

Abstract read
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Knowledge integration in cancer: current landscape and future prospects.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
    Pooled it
  3. Designing Software for Genomics Medicine Service Leaders to Engage Stakeholders.Proceedings. IEEE International Conference on Healthcare Informatics · 2023
    Article
  4. Integrating Rules for Genomic Research, Clinical Care, Public Health Screening and DTC Testing: Creating Translational Law for Translational Genomics.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2020
    Article
  5. Article
  6. Review
  7. Mapping the Ethics of Translational Genomics: Situating Return of Results and Navigating the Research-Clinical Divide.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2015
    Article
  8. Medicine. Big data meets public health.Science (New York, N.Y.) · 2014
    Article
  9. Article
  10. Integrating genetic and genomic information into effective cancer care in diverse populations.Annals of oncology : official journal of the European Society for Medical Oncology · 2013
    Article
  11. The arrival of genomic medicine to the clinic is only the beginning of the journey.Genetics in medicine : official journal of the American College of Medical Genetics · 2013
    Article
  12. "Drivers" of translational cancer epidemiology in the 21st century: needs and opportunities.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muin J KhouryOffice of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA. muk1@cdc.gov
Marta Gwinn
W David Dotson
Sheri D Schully

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Three articles in this issue of Genetics in Medicine describe examples of "knowledge integration," involving methods for generating and synthesizing rapidly emerging information on health-related genomic technologies and engaging stakeholders around the evidence. Knowledge integration, the central process in translating genomic research, involves three closely related, iterative components: knowledge management, knowledge synthesis, and knowledge translation. Knowledge management is the ongoing process of obtaining, organizing, and displaying evolving evidence. For example, horizon scanning and "infoveillance" use emerging technologies to scan databases, registries, publications, and cyberspace for information on genomic applications. Knowledge synthesis is the process of conducting systematic reviews using a priori rules of evidence. For example, methods including meta-analysis, decision analysis, and modeling can be used to combine information from basic, clinical, and population research. Knowledge translation refers to stakeholder engagement and brokering to influence policy, guidelines and recommendations, as well as the research agenda to close knowledge gaps. The ultrarapid production of information requires adequate public and private resources for knowledge integration to support the evidence-based development of genomic medicine.

Indexed as

Knowledge ManagementTranslational Research, BiomedicalDecision Support TechniquesEvidence-Based MedicineGenomicsHumansInformation DisseminationMeta-Analysis as TopicResearch DesignReview Literature as Topic

Identifiers

PMID22555656
PMCPMC4681509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.