ArticleAJNR. American journal of neuroradiology2012
Hemodynamic alterations in vertebrobasilar large artery disease assessed by arterial spin-labeling MR imaging.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors.Cerebral cortex (New York, N.Y. : 1991) · 2015Trial
- Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.Magnetic resonance in medicine · 2024Review
- Perfusion-MRI is a Poor Indicator of Hemodynamic Compromise in Vertebrobasilar Disease in the VERiTAS Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- A general framework for optimizing arterial spin labeling MRI experiments.Magnetic resonance in medicine · 2019Article
- Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study.Journal of magnetic resonance imaging : JMRI · 2018Article
- Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity.AJNR. American journal of neuroradiology · 2017Article
- White Matter Hyperintensity Volume and Cerebral Perfusion in Older Individuals with Hypertension Using Arterial Spin-Labeling.AJNR. American journal of neuroradiology · 2016Article
- A neuroradiologist's guide to arterial spin labeling MRI in clinical practice.Neuroradiology · 2015Review
- Rapid 3D dynamic arterial spin labeling with a sparse model-based image reconstruction.NeuroImage · 2015Article
- Regional cerebral arterial transit time hemodynamics correlate with vascular risk factors and cognitive function in men with coronary artery disease.AJNR. American journal of neuroradiology · 2015Article
- Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.Magnetic resonance in medicine · 2015Review
- Prognostic value of blood flow estimated by arterial spin labeling and dynamic susceptibility contrast-enhanced MR imaging in high-grade gliomas.Journal of neuro-oncology · 2014Article
- Cerebral blood flow quantification using vessel-encoded arterial spin labeling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Diagnosis and management of vertebrobasilar insufficiency.Current treatment options in cardiovascular medicine · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeVB artery stenosis is associated with a high risk of recurrent ischemic events, and knowledge about the hemodynamic relevance of VB stenosis is important for clinical decision making. In this study, multiple inflow pulsed ASL MR imaging was assessed for its ability to measure CBF and ATT in patients with VB disease. MATERIALS AND
methodsASL was performed on a 3T MR imaging scanner in 41 participants. Twenty-one patients had a history of ischemic events in the VB circulation (14 men, 7 women, age 66 ± 11 years). Clinical data and CE-MRA were used to classify VB disease severity. Twenty age-matched adults were controls. Group and within-VB analyses were performed. Mean CBF and ATT values in the ROIs were adjusted by excluding voxels that did not produce a reliable ASL estimate.
resultsCBF was reduced (P < .003) in patients compared with controls, which was significant after excluding voxels with a poor fit. Differences in ATT between patients and controls were not significant after voxel correction. There was a strong correlation between CBF and ATT among patients. Finally, ATT was significantly correlated with VB disease severity (P = .026).
conclusionsMultiple inflow ASL distinguished patients with VB disease from age matched-controls. VB disease rating was associated with prolonged ATT downstream. ASL may have diagnostic potential among patients in whom risk of intervention is high.
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