Evidence map›Paper›PMID 22554892›Full record

ArticleGenetics2012

A role for siRNA in X-chromosome dosage compensation in Drosophila melanogaster.

Debashish U Menon, Victoria H Meller

Abstract read
In one paragraph

Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Functional Significance of Satellite DNAs: Insights FromFrontiers in cell and developmental biology · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Debashish U MenonDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Victoria H Meller

Funding

Small RNA and whole chromosome recognition in Drosophila melanogaster.R01GM093110 · NIGMS · WAYNE STATE UNIVERSITY · PI MELLER, VICTORIA H · 2011 to 2019
$2.3M
NIGMS NIH HHS GM093110NIGMS NIH HHS R01 GM093110
6 · The paper itself

Abstract

Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.

Indexed as

AnimalsDosage Compensation, GeneticDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesMaleMutationRNA-Binding ProteinsRNA, Small InterferingTranscription FactorsX ChromosomeDrosophila ProteinsPabp2 protein, DrosophilaRNA-Binding ProteinsRNA, Small InterferingroX1 protein, DrosophilaTranscription Factors

Identifiers

PMID22554892
PMCPMC3389965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.