Evidence map›Paper›PMID 22554780›Full record

ArticleNeuroscience2012

Differential effects of acute and regular physical exercise on cognition and affect.

M E Hopkins, F C Davis, M R Vantieghem, P J Whalen, D J Bucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Games for health journal · 2023
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  18. Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin.International journal of molecular sciences · 2024
    Article
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  20. Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M E HopkinsDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
F C Davis
M R Vantieghem
P J Whalen
D J Bucci

Funding

Prefrontal-Amygdala Interactions in Social LearningR01MH080716 · NIMH · DARTMOUTH COLLEGE · PI WHALEN, PAUL J · 2007 to 2016
$3.6M
A Translational Approach to Evaluating the Effects of Physical Activity on ADHDR01MH082893 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GREEN, JOHN T, HOZA, BETSY · 2009 to 2013
$3.1M
NIMH NIH HHS R01 MH080716NIMH NIH HHS R01MH080716NIMH NIH HHS R01 MH082893NIMH NIH HHS R01MH082893
6 · The paper itself

Abstract

The effects of regular exercise versus a single bout of exercise on cognition, anxiety, and mood were systematically examined in healthy, sedentary young adults who were genotyped to determine brain-derived neurotrophic factor (BDNF) allelic status (i.e., Val-Val or Val66Met polymorphism). Participants were evaluated on novel object recognition (NOR) memory and a battery of mental health surveys before and after engaging in either (a) a 4-week exercise program, with exercise on the final test day, (b) a 4-week exercise program, without exercise on the final test day, (c) a single bout of exercise on the final test day, or (d) remaining sedentary between test days. Exercise enhanced object recognition memory and produced a beneficial decrease in perceived stress, but only in participants who exercised for 4 weeks including the final day of testing. In contrast, a single bout of exercise did not affect recognition memory and resulted in increased perceived stress levels. An additional novel finding was that the improvements on the NOR task were observed exclusively in participants who were homozygous for the BDNF Val allele, indicating that altered activity-dependent release of BDNF in Met allele carriers may attenuate the cognitive benefits of exercise. Importantly, exercise-induced changes in cognition were not correlated with changes in mood/anxiety, suggesting that separate neural systems mediate these effects. These data in humans mirror recent data from our group in rodents. Taken together, these current findings provide new insights into the behavioral and neural mechanisms that mediate the effects of physical exercise on memory and mental health in humans.

Indexed as

Activities of Daily LivingAdolescentAdultAffectBrain-Derived Neurotrophic FactorCognitionExerciseGenetic TestingHumansMethionineMood DisordersNeuropsychological TestsPolymorphism, Single NucleotidePsychiatric Status Rating ScalesRecognition, PsychologyStress, PsychologicalBrain-Derived Neurotrophic FactorMethionineValine

Identifiers

PMID22554780
PMCPMC3374855

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.