Evidence map›Paper›PMID 22554593›Full record

ArticleUrology2012

Controlled metabolic diet reduces calcium oxalate supersaturation but not oxalate excretion after bariatric surgery.

Ran Pang, Michael P Linnes, Helen M O'Connor, Xujian Li, Eric Bergstralh, John C Lieske

Open access · greenAbstract read
In one paragraph

Article in Urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Twenty-four-hour urine oxalate and risk of chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Observational
  3. Article
  4. Article
  5. Subsequent urinary stone events are predicted by the magnitude of urinary oxalate excretion in enteric hyperoxaluria.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Kidney Stones After Bariatric Surgery: Risk Assessment and Mitigation.Bariatric surgical practice and patient care · 2017
    Review
  10. Enteric hyperoxaluria: an important cause of end-stage kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016
    Review
  11. Review
  12. Kidney stone risk following Roux-en-Y gastric bypass surgery.Translational andrology and urology · 2014
    Article
  13. Review
  14. Metabolic and endocrinological factors related to nephrolithiasis pre and post multiple techniques of bariatric surgery: a sistematic review.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2014
    Review
  15. Update on oxalate crystal disease.Current rheumatology reports · 2013
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ran PangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905, USA.
Michael P Linnes
Helen M O'Connor
Xujian Li
Eric Bergstralh
John C Lieske
Mayo Clinic · USMayo Clinic in Florida · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Primary HyperoxaluriaU54DK083908 · NIDDK · MAYO CLINIC ROCHESTER · PI MILLINER, DAWN SCHMAUTZ · 2009 to 2018
$12.3M
Mayo Clinic Urology O'Brien Research CenterP50DK083007 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 2008 to 2012
$5.3M
Use of symbiotics to reduce urinary oxalate excretionR21AT002534 · NCCIH · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 2005 to 2007
$579k
NCCIH NIH HHS AT R21AT2534NCCIH NIH HHS R21 AT002534NCRR NIH HHS UL1 RR024150NIDDK NIH HHS P50 DK083007NIDDK NIH HHS U54 DK082908NIDDK NIH HHS U54 DK083908
6 · The paper itself

Abstract

objectiveTo identify the effect of a controlled metabolic diet on reducing urinary calcium oxalate (CaOx) supersaturation in subjects with hyperoxaluric nephrolithiasis after potentially malabsorptive forms of bariatric surgery.

methodsSubjects with a history of CaOx kidney stones and mild hyperoxaluria after bariatric surgery (n = 9) collected baseline 24-hour urine samples while consuming a free choice diet. They were then instructed to consume a controlled diet low in oxalate (70-80 mg/d), normal in calcium (1000 mg/d), and moderate in protein before 2 final 24-hour urine collections.

resultsOverall, the urinary CaOx supersaturation decreased from 1.97 ± 0.49 delta Gibbs (DG) with the free choice diet to 1.13 ± 0.75 DG with the controlled diet (P < .01). This occurred in the absence of a significant change in urinary oxalate excretion (0.69 ± 0.29 mmol/d with the free choice diet compared with 0.66 ± 0.38 mmol/d with the controlled diet). Urinary volume, citrate, and pH all increased, although not significantly (P > .05), contributing to the significant CaOx supersaturation change.

conclusionA controlled metabolic diet normal in calcium, moderate in protein, and reduced in oxalate can positively affect urinary CaOx supersaturation after bariatric surgery. However, this diet did not appear to decrease urinary oxalate excretion. Therefore, restriction of dietary oxalate alone might not be enough to reduce urinary oxalate excretion to normal levels in this group of patients with known enteric hyperoxaluria. Additional strategies could be necessary, such as the use of oral calcium supplements as oxalate binders and a lower fat diet.

Indexed as

Bariatric SurgeryDietCalcium OxalateFemaleHumansMaleMiddle AgedOxalatesCalcium OxalateOxalates

Identifiers

PMID22554593
PMCPMC3411876
OpenAlexW2147052375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.