ArticleBiological psychiatry2012
Predictive pursuit association with deficits in working memory in psychosis.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences.European archives of psychiatry and clinical neuroscience · 2026Article
- Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis.Schizophrenia bulletin · 2020Article
- Disrupted Corollary Discharge in Schizophrenia: Evidence From the Oculomotor System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.Neuropsychopharmacology reports · 2019Review
- Schizotypy and smooth pursuit eye movements as potential endophenotypes of obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Oculomotor Prediction: A Window into the Psychotic Mind.Trends in cognitive sciences · 2017Review
- Visual and non-visual motion information processing during pursuit eye tracking in schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2017Article
- Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension.Schizophrenia bulletin · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeficits in smooth pursuit eye movements are an established phenotype for schizophrenia (SZ) and are being investigated as a potential liability marker for bipolar disorder. Although the molecular determinants of this deficit are still unclear, research has verified deficits in predictive pursuit mechanisms in SZ. Because predictive pursuit might depend on the working memory system, we have hypothesized a relationship between the two in healthy control subjects (HC) and SZ and here examine whether it extends to psychotic bipolar disorder (BDP).
methodsVolunteers with SZ (n = 38), BDP (n = 31), and HC (n = 32) performed a novel eye movement task to assess predictive pursuit as well as a standard visuospatial measure of working memory.
resultsIndividuals with SZ and BDP both showed reduced predictive pursuit gain compared with HC (p < .05). Moreover, each patient group showed worse performance in visuospatial working memory compared with control subjects (p < .05). A strong correlation (r = .53, p = .007) was found between predictive pursuit gain and working memory in HC, a relationship that showed a trend correlation within the BDP group but not among SZ.
conclusionsIndividuals with SZ and BDP showed similar deficits in predictive pursuit, suggesting that this alteration could be a characteristic trait of the psychosis domain. The correlation between predictive pursuit and working memory in HC supports the assumption that working memory is related to predictive pursuit eye movements; however, the degradation of working memory in people with psychosis disrupts its association with eye-tracking behavior.
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