ArticleInorganic chemistry2012
Nitrosation, thiols, and hemoglobin: energetics and kinetics.
Article in Inorganic chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Profiling the landscape of cysteine posttranslational modifications in brain aging and neurodegeneration.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Unraveling the Molecular Mechanism ofInorganic chemistry · 2023Article
- Myoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation.Nitric oxide : biology and chemistry · 2020Article
- A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation.Molecular cell · 2018Article
- Computational Structural Biology ofFrontiers in oncology · 2018Review
- Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.Antioxidants & redox signaling · 2017Review
- Nitrosopersulfide (SSNOInterface focus · 2017Article
- Recent insights into nitrite signaling processes in blood.Biological chemistry · 2017Article
- Nitrite-Mediated Hypoxic Vasodilation Predicted from Mathematical Modeling and Quantified fromFrontiers in physiology · 2017Article
- A mathematical model for the role of NNitric oxide : biology and chemistry · 2016Article
- Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride.Nature chemical biology · 2015Article
- Mechanisms of human erythrocytic bioactivation of nitrite.The Journal of biological chemistry · 2015Article
- Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties.The Journal of biological chemistry · 2015Article
- Mechanisms of nitrite bioactivation.Nitric oxide : biology and chemistry · 2014Review
- Hemoglobin-mediated nitric oxide signaling.Free radical biology & medicine · 2013Review
- Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling.Current opinion in chemical biology · 2012Review
- Chemical characterization of the smallest S-nitrosothiol, HSNO; cellular cross-talk of H2S and S-nitrosothiols.Journal of the American Chemical Society · 2012Article
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Abstract
Nitrosothiols are powerful vasodilators. Although the mechanism of their formation near neutral pH is an area of intense research, neither the energetics nor the kinetics of this reaction or of subsequent reactions have been addressed. The following considerations may help to guide experiments. (1) The standard Gibbs energy for the homolysis reaction RSNO → RS(•) + NO(•)(aq) is +110 ± 5 kJ mol(-1). (2) The electrode potential of the RSNO, H(+)/RSH, NO(•)(aq) couple is -0.20 ± 0.06 V at pH 7. (3) Thiol nitrosation by NO(2)(-) is favorable by 37 ± 5 kJ mol(-1) at pH 7. (4) N(2)O(3) is not involved in in vivo nitrosation mechanisms for thermodynamic--its formation from NO(2)(-) costs 59 kJ mol(-1)--or kinetic--the reaction being second-order in NO(2)(-)--reasons. (5) Hemoglobin (Hb) cannot catalyze formation of N(2)O(3), be it via the intermediacy of the reaction of Hb[FeNO(2)](2+) with NO(•) (+81 kJ mol(-1)) or reaction of Hb[FeNO](3+) with NO(2)(-) (+88 kJ mol(-1)). (6) Energetically and kinetically viable are nitrosations that involve HNO(2) or NO(•) in the presence of an electron acceptor with an electrode potential higher than -0.20 V. These considerations are derived from existing thermochemical and kinetics data.
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