ArticleInternational journal of ophthalmology2011
Modulation of TGFβ(2) and dopamine by PKC in retinal Müller cells of guinea pig myopic eye.
Article in International journal of ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Human aqueous humor levels of TGF- β2: relationship with axial length.BioMed research international · 2014Trial
- Roles of growth factors in eye development and ophthalmic diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- Form-Deprivation and Lens-Induced Myopia Are Similarly Affected by Pharmacological Manipulation of the Dopaminergic System in Chicks.Investigative ophthalmology & visual science · 2020Article
- Effectiveness and safety of topical levodopa in a chick model of myopia.Scientific reports · 2019Article
- Effect of MT3 on Retinal and Choroidal TGF-Journal of ophthalmology · 2017Article
- Mechanism of the DL-alpha-aminoadipic acid inhibitory effect on form-deprived myopia in guinea pig.International journal of ophthalmology · 2013Article
- Retinoic acid metabolic change in retina and choroid of the guinea pig with lens-induced myopia.International journal of ophthalmology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of protein kinase C (PKC) on transforming growth factor-β(2) (TGFβ(2)) and dopamine in retinal Müller cells of guinea pig myopic eye.
methodsMyopia was induced by translucent goggles in guinea pig, whose retinal Müller cells were cultured using the enzyme-digesting method. Retinal Müller cells were divided into 5 groups: normal control, myopia, myopia plus GF109203X, myopia plus PMA, myopia plus DMSO. PKC activities were detected by the non-radioactive methods. TGFβ(2) and tyrosine hydroxylase (TH) proteins were analyzed by Western Blotting in retinal Müller cells. Dopamine was determined by the high-performance liquid chromatography-electrochemical detection in suspensions.
resultsAfter 14 days deprived, the occluded eyes became myopic with ocular axle elongating. Müller cells of guinea pigs were obtained using enzyme digestion. Compared with normal control group, the increase in PKC activity and the up-regulation in TGFβ(2) expression were found in retinal Müller cells of myopic eyes, with the decrease of TH and dopamine content (P<0.05). After PKC activated by PMA, TGFβ(2) and TH content were up-regulated with the increase of dopamine content (P<0.05). While the PKC activities was inhibited by GF109203X, proteins of TGFβ(2) and TH were down-regulated in the myopic eyes, with the decrease of dopamine content (P<0.05).
conclusionTGFβ(2) and dopamine are modulated by PKC in Müller cells of the myopic eyes in guinea pig.
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