ArticleSpermatogenesis2012
Genetically engineered immune privileged Sertoli cells: A new road to cell based gene therapy.
Article in Spermatogenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Safety and efficacy of autologous bone marrow aspirate concentrate injection for idiopathic male infertility: A comparative study.World journal of experimental medicine · 2025Article
- Microencapsulated Sertoli cells sustain myoblast proliferation without affecting the myogenic potential.Data in brief · 2022Article
- Drug transport across the blood-testis barrier.American journal of translational research · 2022Review
- Characterization of rodent Sertoli cell primary cultures.Molecular reproduction and development · 2020Review
- Bisphenols Threaten Male Reproductive Health via Testicular Cells.Frontiers in endocrinology · 2020Review
- Manipulation of spermatogonial stem cells in livestock species.Journal of animal science and biotechnology · 2019Review
- In Vitro Derivation of Functional Sertoli-Like Cells from Mouse Embryonic Stem Cells.Cell transplantation · 2018Article
- Sertoli Cells Engineered to Express Insulin to Lower Blood Glucose in Diabetic Mice.DNA and cell biology · 2018Article
- Signaling pathways regulating blood-tissue barriers - Lesson from the testis.Biochimica et biophysica acta. Biomembranes · 2018Review
- Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis.International journal of molecular sciences · 2017Article
- Review
- Nondividing, postpubertal rat sertoli cells resumed proliferation after transplantation.Biology of reproduction · 2014Article
- The apical ES-BTB-BM functional axis is an emerging target for toxicant-induced infertility.Trends in molecular medicine · 2013Article
- Dual role of immune cells in the testis: Protective or pathogenic for germ cells?Spermatogenesis · 2013Article
- Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.Spermatogenesis · 2012Article
- Filamin A: A regulator of blood-testis barrier assembly during post-natal development.Spermatogenesis · 2012Article
- Altered Expression of Toll-Like Receptors and Key Signaling Genes in Sertoli Cells of Azoospermic Patients.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sertoli cells are immune privileged cells, important for controlling the immune response to male germ cells as well as maintaining the tolerogenic environment in the testis. Additionally, ectopic Sertoli cells have been shown to survive and protect co-grafted cells when transplanted across immunological barriers. The survival of ectopic Sertoli cells has led to the idea that they could be used in cell based gene therapy. In this review, we provide a brief overview of testis immune privilege and Sertoli cell transplantation, factors contributing to Sertoli cell immune privilege, the challenges faced by viral vector gene therapy, the use of immune privileged cells in cell based gene therapy and describe several recent studies on the use of genetically engineered Sertoli cells to provide continuous delivery of therapeutic proteins.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.