ArticleSpermatogenesis2012
In search of suitable in vitro models to study germ cell movement across the blood-testis barrier.
Article in Spermatogenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- What do we know about blood-testis barrier? current understanding of its structure and physiology.Frontiers in cell and developmental biology · 2023Review
- Mechanistic Insights into PFOS-Mediated Sertoli Cell Injury.Trends in molecular medicine · 2018Review
- The cell adhesion molecule BT-IgSF is essential for a functional blood-testis barrier and male fertility in mice.The Journal of biological chemistry · 2017Article
- The Warburg effect revisited--lesson from the Sertoli cell.Medicinal research reviews · 2015Review
- Long-term culture and analysis of cashmere goat Sertoli cells.In vitro cellular & developmental biology. Animal · 2014Article
- Sertolin mediates blood-testis barrier restructuring.Endocrinology · 2014Article
- Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function.Tissue barriers · 2013Review
- Intercellular adhesion molecules (ICAMs) and spermatogenesis.Human reproduction updateReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The movement of preleptotene/leptotene spermatocytes across the blood-testis barrier, also known as the Sertoli cell barrier, during stages VIII to XI of the seminiferous epithelial cycle is one of the most important cellular events taking place in the mammalian testis. Without the passage of spermatocytes, spermatogenesis would be halted, resulting in transient or permanent sterility. Unfortunately, we have very little knowledge on how preleptotene/leptotene spermatocytes cross the blood-testis barrier. While we know cytokines, proteases and androgens to mediate Sertoli cell junction restructuring, most data continue to be derived from experiments using Sertoli cells cultured alone in two dimensions. Thus, additional in vitro models which include germ cells must come into use. In this Commentary, we hope to shed new light on how we may better study spermatocyte movement across the BTB.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.