Evidence map›Paper›PMID 22553396›Full record

ReviewWorld journal of gastroenterology2012

Epidemiology and clinical course of Crohn's disease: results from observational studies.

Øistein Hovde, Bjørn A Moum

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03291743 (The Biologic Onset of Crohn's Disease), which is not on this map. Cited by 46 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 4 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03291743 naterminatednot on this mapstarted 2017, after this paper: background citation

The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives

TypeinterventionalSponsorCarilion ClinicRan2017 to 2022Enrolled38ConditionsCrohn Disease, Genetic Predisposition, IBDArmsCapsule endoscopy
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Adalimumab for induction of remission in Crohn's disease.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Crohn's disease is associated with higher rates of implant-related complications following primary total knee arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Article
  12. Matrix metalloproteinases in intestinal fibrosis.Journal of Crohn's & colitis · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Orofacial granulomatosis: a questionnaire study among Norwegian dental clinicians.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Øistein HovdeDepartment of Internal Medicine/Gastroenterology, Innlandet Hospital Trust, 2819 Gjøvik, Oppland, Norway. oistein.hovde@sykehuset-innlandet.no
Bjørn A Moum
Innlandet Hospital Trust · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors review the clinical outcome in patients with Crohn's disease (CD) based on studies describing the natural course of the disease. Population-based studies have demonstrated that the incidence rates and prevalence rates for CD have increased since the mid-1970s. The authors search for English language articles from 1980 until 2011. Geographical variations, incidence, prevalence, smoking habits, sex, mortality and medications are investigated. An increasing incidence and prevalence of CD have been found over the last three decades. The disease seems to be most common in northern Europe and North America, but is probably increasing also in Asia and Africa. Smoking is associated with an increased risk of developing CD. Age < 40 at diagnosis, penetrating/stricturing complications, need for systemic steroids, and disease location in terminal ileum are factors associated with higher relapse rates. A slight predominance of women diagnosed with CD has been found. Ileocecal resection is the most commonly performed surgical procedure, and within the first five years after the diagnosis about one third of the patients have had intestinal surgery. Smoking is associated with a worse clinical course and with increased risk of flare-ups. In most studies the overall mortality is comparable to the background population. To date, the most effective treatment options in acute flares are glucocorticosteroids and tumor necrosis factor (TNF)-α-blockers. Azathioprine/methotrexate and TNF-α-blockers are effective in maintaining remission.

Indexed as

AppendectomyCost of IllnessC-Reactive ProteinCrohn DiseaseFemaleHumansIncidenceMaleRisk FactorsSmokingC-Reactive ProteinCrohn’s diseaseDiagnosisEpidemiologyExtra-intestinal manifestationsSmokingTherapy

Identifiers

PMID22553396
PMCPMC3332285
OpenAlexW1963966837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.