ArticleNaunyn-Schmiedeberg's archives of pharmacology1990
Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein via presynaptic 5-HT receptors similar to the 5-HT 1D subtype.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).Naunyn-Schmiedeberg's archives of pharmacology · 2021Review
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Oh, the places you'll go! My many colored serotonin (apologies to Dr. Seuss).American journal of physiology. Heart and circulatory physiology · 2016Review
- 5-Hydroxytryptamine does not reduce sympathetic nerve activity or neuroeffector function in the splanchnic circulation.European journal of pharmacology · 2015Article
- Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome.Techniques in coloproctology · 2014Review
- 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved.BMC pharmacology · 2012Article
- Serotonin and blood pressure regulation.Pharmacological reviews · 2012Review
- 5-hydroxtryptamine receptors in systemic hypertension: an arterial focus.Cardiovascular therapeutics · 2011Review
- Stress-induced activity in the locus coeruleus is not sensitive to stressor controllability.Brain research · 2009Article
- Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.Naunyn-Schmiedeberg's archives of pharmacology · 2007Review
- Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons.The Journal of physiology · 1999Article
- Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Characterization of prejunctional 5-HT receptors mediating inhibition of sympathetic vasopressor responses in the pithed rat.British journal of pharmacology · 1995Article
- Effects of 5-HT receptor agonists on depolarization-induced [3H]-noradrenaline release in rabbit hippocampus and human neocortex.British journal of pharmacology · 1995Article
- 5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Clinical pharmacology, physiology and pathophysiology of superficial veins--2.British journal of clinical pharmacology · 1994Review
- The 5-HT1-like receptor mediating the increase in canine external carotid blood flow: close resemblance to the 5-HT1D subtype.British journal of pharmacology · 1994Article
- Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Endothelium-dependent relaxation of porcine pulmonary arteries via 5-HT1C-like receptors.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
- Effects of 6-hydroxydopamine on pre- and post-junctional 5-HT1-like receptor-mediated responses in dog saphenous vein.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human saphenous vein preincubated with [3H]noradrenaline was used to determine the pharmacological properties of the release-inhibiting presynaptic serotonin (5-HT) receptor on the sympathetic nerves. The overflow of tritium evoked by transmural electrical stimulation (2 Hz) was concentration-dependently inhibited by drugs known to stimulate 5-HT receptors in the following rank order: oxymetazoline greater than or equal to 5-HT greater than 5-carboxamidotryptamine = 5-methoxytryptamine = sumatriptan greater than tryptamine greater than N,N(CH3)2-5-HT = yohimbine = 8-hydroxy-2-(di-n-propylamino)-tetraline. The potencies of these agonists in inhibiting overflow were significantly correlated with their affinities for 5-HT1B and 5-HT1D binding sites, but not with those for 5-HT1A or 5-HT1C binding sites. 5-Aminotryptamine, methysergide, ipsapirone, cyanopindolol, SDZ 21009 and metergoline dit not produce a significant inhibition. Metitepine and methysergide antagonized the inhibitory effect of 5-HT, whereas spiroxatrine, propranolol, ketanserin and ICS 205-930 did not. These data exclude the idea that the inhibitory presynaptic 5-HT receptor on the sympathetic nerves belongs to the 5-HT2 and 5-HT3 receptor class; the pattern of agonist potencies suggests that the receptor is very similar to the 5-HT1D receptor subtype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.