ArticleMarine biotechnology (New York, N.Y.)2012
Mapping of DNA sex-specific markers and genes related to sex differentiation in turbot (Scophthalmus maximus).
Article in Marine biotechnology (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 49 citations in OpenAlex.
- Characterization of scp3 and Its Expression Dynamics Identifies the Critical Period for Meiotic Initiation in Female Turbot (Scophthalmus maximus).Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Article
- Article
- QTL Fine Mapping for Sex Determination Region in Bighead Carp (Hypophthalmichthys nobilis) and Comparison with Silver Carp (Hypophthalmichthys molitrix).Marine biotechnology (New York, N.Y.) · 2020Article
- Integrated gene mapping and synteny studies give insights into the evolution of a sex proto-chromosome in Solea senegalensis.Chromosoma · 2017Article
- Mapping QTL for Resistance Against Viral Nervous Necrosis Disease in Asian Seabass.Marine biotechnology (New York, N.Y.) · 2016Article
- Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).BMC genomics · 2015Article
- Identification of Sex-Linked SNPs and Sex-Determining Regions in the Yellowtail Genome.Marine biotechnology (New York, N.Y.) · 2015Article
- Combinatorial immunotherapy of sorafenib and blockade of programmed death-ligand 1 induces effective natural killer cell responses against hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Article
- SOX10 is a novel oncogene in hepatocellular carcinoma through Wnt/β-catenin/TCF4 cascade.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Fine mapping and evolution of the major sex determining region in turbot (Scophthalmus maximus).G3 (Bethesda, Md.) · 2014Article
- Consolidation of the genetic and cytogenetic maps of turbot (Scophthalmus maximus) using FISH with BAC clones.Chromosoma · 2014Article
- Oncogenicity of the transcription factor SOX8 in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- A sex-associated sequence identified by RAPD screening in gynogenetic individuals of turbot (Scophthalmus maximus).Molecular biology reports · 2014Article
- Article
- Genetic differentiation and efficient sex-specific marker development of a pair of Y- and X-linked markers in yellow catfish.International journal of biological sciences · 2013Article
- Male-biased genes in catfish as revealed by RNA-Seq analysis of the testis transcriptome.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Production of all-female populations in turbot can increase farmer's benefits since sexual dimorphism in growth in this species is among the highest within marine fish, turbot females reaching commercial size 3-6 months earlier than males. Puberty in males occurs earlier than in females, which additionally slows their growth. Thus, elucidating the mechanisms of sex determination and gonad differentiation is a relevant goal for turbot production. A ZZ/ZW sex determination mechanism has been suggested for this species, and four sex-related quantitative trait loci (QTL) were detected, the major one located in linkage group (LG) 5 and the three minor ones in LG6, LG8, and LG21. In the present work, we carried out a linkage analysis for several sex-related markers: (1) three anonymous sex-associated RAPD and (2) several candidate genes related to sex determination and gonad differentiation in other species (Sox3, Sox6, Sox8, Sox9, Sox17, Sox19, Amh, Dmrta2, Cyp19a, Cyp19b). We focused our attention on their co-localization with the major and minor sex-related QTL trying to approach to the master sex-determining gene of this species. Previously described growth-related QTL were also considered since the association observed between growth and sex determination in fish. Amh, Dmrta2, and one RAPD were located in LG5, while Sox9 and Sox17 (LG21), Cyp19b (LG6), and a second RAPD (LG8) co-mapped with suggestive sex-related QTL, thus supporting further analyses on these genes to elucidate the genetic basis of this relevant trait for turbot farming.
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