Evidence map›Paper›PMID 22552883›Full record

ArticleInternational journal of hematology2012

Rituximab in a child with autoimmune thrombotic thrombocytopenic purpura refractory to plasma exchange.

Parameswaran Narayanan, Aparna Jayaraman, Rashi S Rustagi, S Mahadevan, Sreejith Parameswaran

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Parameswaran NarayananDepartment of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry, India. narayanan@jipmer.net
Aparna Jayaraman
Rashi S Rustagi
S Mahadevan
Sreejith Parameswaran
Jawaharlal Institute of Post Graduate Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nine-year-old girl presented with headache, purpura and mild left hemiparesis. Laboratory evaluation revealed thrombotic microangiopathy with ADAMTS13 deficiency, with auto-antibodies to ADAMTS13. She was treated with plasma exchange and steroids, following which she improved transiently, relapsing within 2 months. The relapse was refractory to conventional therapy and rituximab was tried. She had good response to rituximab and has been in remission for the past 12 months. Rituximab may be a promising option for children with acquired TTP refractory to plasma exchange and steroids.

Indexed as

ADAM ProteinsADAMTS13 ProteinAntibodies, Monoclonal, Murine-DerivedAutoimmune DiseasesBrainChildFemaleHumansImmunologic FactorsInfarction, Anterior Cerebral ArteryMagnetic Resonance ImagingPlasma ExchangePurpura, Thrombotic ThrombocytopenicRituximabADAM ProteinsADAMTS13 ProteinADAMTS13 protein, humanAntibodies, Monoclonal, Murine-DerivedImmunologic FactorsRituximab

Identifiers

PMID22552883
OpenAlexW2036500077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.