ArticleMolecular imaging and biology2012
Synthesis of a novel L-methyl-methionine-ICG-Der-02 fluorescent probe for in vivo near infrared imaging of tumors.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging.International journal of nanomedicine · 2025Article
- Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes.Molecules (Basel, Switzerland) · 2024Article
- The application of indocyanine green in guiding prostate cancer treatment.Asian journal of urology · 2023Review
- Research progress of near-infrared fluorescence probes based on indole heptamethine cyanine dyes in vivo and in vitro.BMC chemistry · 2020Review
- Novel harmine derivatives for tumor targeted therapy.Oncotarget · 2015Article
- MUC1 aptamer-based near-infrared fluorescence probes for tumor imaging.Molecular imaging and biology · 2015Article
- Synthesis and characterization of a glycine-modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging.Drug design, development and therapy · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA novel near infrared fluorescent probe, L-methyl-methionine (Met)-ICG-Der-02, was synthesized and characterized for in vivo imaging of tumors and early diagnosis of cancers.
methodMet was conjugated with ICG-Der-02 dye through the amide bond function by ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride/N-hydroxysuccinimide catalysis chemistry. Met-ICG-Der-02 probe uptake was evaluated on PC3, MDA-MB-231, and human embryonic lung fibroblast cell lines. The dynamics of Met-ICG-Der-02 was investigated in athymic nude mice prior to evaluation of the probe targeting capability in prostate and breast cancer models.
resultsMet-ICG-Der-02 was successfully synthesized. Cell experiments demonstrated excellent cellular uptake of Met-ICG-Der-02 on cancer cell lines without cytotoxicity. Optical imaging showed a distinguishable fluorescence signal in the tumor area at 2 h while maximal tumor-to-normal tissue contrast ratio was at 12 h Met-ICG-Der-02 post-injection. Additionally, dynamic study of the probe indicated intestinal and liver-kidney clearance pathways.
conclusionMet-ICG-Der-02 probe is a promising optical imaging agent for tumor diagnosis, especially in their early stage.
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