Evidence map›Paper›PMID 22552698›Full record

ReviewCurrent opinion in otolaryngology & head and neck surgery2011

Efferent modulation of hair cell function.

Richard D Rabbitt, William E Brownell

Abstract readReview
In one paragraph

Review in Current opinion in otolaryngology & head and neck surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Lateral olivocochlear neurons modulate cochlear responses to noise exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Inherent envelope fluctuations in forward masking: Effects of age and hearing loss.The Journal of the Acoustical Society of America · 2023
    Article
  6. Review
  7. Article
  8. Effects of Efferent Activity on Hair Bundle Mechanics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. New treatment options for hearing loss.Nature reviews. Drug discovery · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Richard D RabbittDepartment of Bioengineering, University of Utah, Salt Lake City, Utah, USA.
William E Brownell

Funding

INTRACOCHLEAR ELECTROCHEMICAL GRADIENTSR01DC000354 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI BROWNELL, WILLIAM E, FARRELL, BRENDA FRANCES · 1989 to 2018
$10.4M
Biophysics and Biomechanics of the Semicircular CanalsR01DC006685 · NIDCD · UNIVERSITY OF UTAH · PI RABBITT, RICHARD D · 2005 to 2022
$6.8M
MECHANICS OF THE COCHLEAR OUTER HAIR CELLR01DC002775 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI BROWNELL, WILLIAM E · 1996 to 2011
$5.6M
Micro-Electric Impedance Spectroscopy of Hair CellsR01DC004928 · NIDCD · UNIVERSITY OF UTAH · PI RABBITT, RICHARD D · 2001 to 2009
$3.8M
Synaptic Determinants of Vestibular Afferent DynamicsR01DC008142 · NIDCD · MARINE BIOLOGICAL LABORATORY · PI RABBITT, RICHARD D · 2009 to 2013
$2.5M
Biomechanics of the Semicircular CanalsR55DC006685 · NIDCD · UNIVERSITY OF UTAH · PI RABBITT, RICHARD D · 2004 to 2004
$100k
INDIVIDUAL DIFFERENCES IN BITTER TASTEF32DC000384 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI DELWICHE, JEANNINE F · 1999 to 2000
$32k
NIDCD NIH HHS DC000384NIDCD NIH HHS DC002775NIDCD NIH HHS F32 DC000384NIDCD NIH HHS R01 DC000354NIDCD NIH HHS R01 DC002775NIDCD NIH HHS R01 DC004928NIDCD NIH HHS R01 DC006685NIDCD NIH HHS R01 DC008142NIDCD NIH HHS R01S DC004928NIDCD NIH HHS R55 DC006685
6 · The paper itself

Abstract

purpose of reviewThis review covers the articles published between 2010 and early 2011 that presented new findings on inner-ear efferents and their ability to modulate hair cell function. RECENT

findingsStudies published within the review period have increased our understanding of efferent mechanisms on hair cells in the cochlear and vestibular sensory epithelium and provide insights on efferent contributions to the plasticity of bilateral auditory processing. The central nervous system controls the sensitivity of hair cells to physiological stimuli by regulating the gain of hair cell electromechanical amplification and modulating the efficiency of hair cell-eighth nerve transmission. A notable advance in the last year has been animal and human studies that have examined the contribution of the olivocochlear efferents to sound localization, particularly in a noisy environment. SUMMARY: Acoustic activation of olivocochlear fibers provides a clinical test for the integrity of the peripheral auditory system and has provided new understanding about the function and limitations of the cochlear amplifier. Although similar tests may be possible in the efferent vestibular system, they have not yet been developed. The structural and functional similarities of the sensory epithelia in the inner ear offer hope that testing procedures may be developed that will allow reliable testing of the vestibular hair cell function.

Indexed as

Acoustic StimulationAnimalsCochleaEfferent PathwaysHair Cells, AuditoryHearingHumans

Identifiers

PMID22552698
PMCPMC3343276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.