ArticleJournal of neurophysiology2012
Olfactory modulation by dopamine in the context of aversive learning.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.Journal of neurophysiology · 2026Article
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- The lepidopteran analyst: how caterpillars, moths and butterflies encode taste identity and valence.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- Goal-directed behavior in Tenebrio molitor larvae.Scientific reports · 2024Article
- Neuromodulation and differential learning across mosquito species.Proceedings. Biological sciences · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Antennal-lobe neurons in the moth Helicoverpa armigera: Morphological features of projection neurons, local interneurons, and centrifugal neurons.The Journal of comparative neurology · 2021Article
- Multiple network properties overcome random connectivity to enable stereotypic sensory responses.Nature communications · 2020Article
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- Inhibitory learning of phototaxis by honeybees in a passive-avoidance task.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Olfaction, experience and neural mechanisms underlying mosquito host preference.The Journal of experimental biology · 2018Review
- Modulation of Host Learning in Aedes aegypti Mosquitoes.Current biology : CB · 2018Article
- Biological Mechanisms for Learning: A Computational Model of Olfactory Learning in theFrontiers in computational neuroscience · 2018Article
- Intrinsic and Extrinsic Neuromodulation of Olfactory Processing.Frontiers in cellular neuroscience · 2017Review
- The anatomical basis for modulatory convergence in the antennal lobe of Manduca sexta.The Journal of comparative neurology · 2016Article
- Neuroethology of Olfactory-Guided Behavior and Its Potential Application in the Control of Harmful Insects.Frontiers in physiology · 2016Review
- A Flight Sensory-Motor to Olfactory Processing Circuit in the Moth Manduca sexta.Frontiers in neural circuits · 2016Article
- The neural bases of host plant selection in a Neuroecology framework.Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The need to detect and process sensory cues varies in different behavioral contexts. Plasticity in sensory coding can be achieved by the context-specific release of neuromodulators in restricted brain areas. The context of aversion triggers the release of dopamine in the insect brain, yet the effects of dopamine on sensory coding are unknown. In this study, we characterize the morphology of dopaminergic neurons that innervate each of the antennal lobes (ALs; the first synaptic neuropils of the olfactory system) of the moth Manduca sexta and demonstrate with electrophysiology that dopamine enhances odor-evoked responses of the majority of AL neurons while reducing the responses of a small minority. Because dopamine release in higher brain areas mediates aversive learning we developed a naturalistic, ecologically inspired aversive learning paradigm in which an innately appetitive host plant floral odor is paired with a mimic of the aversive nectar of herbivorized host plants. This pairing resulted in a decrease in feeding behavior that was blocked when dopamine receptor antagonists were injected directly into the ALs. These results suggest that a transient dopaminergic enhancement of sensory output from the AL contributes to the formation of aversive memories. We propose a model of olfactory modulation in which specific contexts trigger the release of different neuromodulators in the AL to increase olfactory output to downstream areas of processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.