ArticleJournal of neurophysiology2012
Changes in multifinger interaction and coordination in Parkinson's disease.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06435078 (Developments of Novel Virtual Visual and Haptic Stimulation Systems for the Elderly), which is not on this map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developments of Novel Virtual Visual and Haptic Stimulation Systems for the Elderly
Who cites it
83 citing papers in PubMed, 167 citations in OpenAlex.
- Dopaminergic modulation of multi-muscle synergies in postural tasks performed by patients with Parkinson's disease.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2017Trial
- Finger force changes in the absence of visual feedback in patients with Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Trial
- Effects of muscle vibration on multi-finger interaction and coordination.Experimental brain research · 2013Trial
- Improving finger coordination in young and elderly persons.Experimental brain research · 2013Trial
- Changes in peripheral sensory afference do not alter predictive motor planning: evidence from carpal tunnel syndrome.Experimental brain research · 2026Article
- Effects of first-step constraints on multi-muscle synergies and early postural adjustments during step initiation.Experimental brain research · 2026Article
- Force production with a subset of fingers: two aspects of unintentional finger involvement.Experimental brain research · 2026Article
- Changes in synergy formation and modulation during cyclic finger force production tasks in female adults with dystonic cerebral palsy.Experimental brain research · 2026Article
- Two strategies of anticipatory mechanism during change in frequency of cyclic multi-finger force production in isometric conditions.Experimental brain research · 2026Article
- Functional changes in spinal circuitry in essential tremor revealed with analysis of intramuscle synergies.Journal of neurophysiology · 2026Article
- Altered regularity and stability of multi-finger force production in individuals with mild cognitive impairment.Frontiers in human neuroscience · 2026Article
- Stability of performance in a hierarchical system during isometric force production and effects of visual feedback.Experimental brain research · 2025Article
- Carpal tunnel release surgery restores force control but not force coordination in CTS patients.Scientific reports · 2025Article
- Analysis of High-Dimensional Coordination in Human Movement Using Variance Spectrum Scaling and Intrinsic Dimensionality.Entropy (Basel, Switzerland) · 2025Article
- Characterizing Hand Function in Parkinson's Disease Patients with a Self-Administered Electronic Manual Dexterity Test.Movement disorders clinical practice · 2025Article
- Force drifts and matching errors in the lower extremities: implications for the control and perception of foot force.Experimental brain research · 2024Article
- Task demands modulate distal limb handedness: A comparative analysis of prehensile synergies of the dominant and non-dominant hand.Scientific reports · 2024Article
- Two aspects of feed-forward control of action stability: effects of action speed and unexpected events.Experimental brain research · 2024Article
- Force matching: motor effects that are not reported by the actor.Experimental brain research · 2024Article
- Motor unit-based synergies in a non-compartmentalized muscle.Experimental brain research · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In this study, we tested several hypotheses related to changes in finger interaction and multifinger synergies during multifinger force production tasks in Parkinson's disease. Ten patients with Parkinson's disease, mostly early stage, and 11 healthy control subjects participated in the study. Synergies were defined as covaried adjustment of commands to fingers that stabilized the total force produced by the hand. Both Parkinson's disease patients and control subjects performed accurate isometric force production tasks with the fingers of both the dominant and nondominant hands. The Parkinson's disease patients showed significantly lower maximal finger forces and higher unintended force production (enslaving). These observations suggest that changes in supraspinal control have a major effect on finger individuation. The synergy indexes in the patients were weaker in both steady-state and cyclic force production tasks compared with the controls. These indexes also were stronger in the left (nondominant) hand in support of the dynamic-dominance hypothesis. Half of the patients could not perform the cyclic task at the highest frequency (2 Hz). Anticipatory adjustments of synergies prior to a quick force pulse production were delayed and reduced in the patients compared with the controls. Similar differences were observed between the asymptomatic hands of the patients with symptoms limited to one side of the body and matched hands of control subjects. Our study demonstrates that the elusive changes in motor coordination in Parkinson's disease can be quantified objectively, even in patients at a relatively early stage of the disease. The results suggest an important role of the basal ganglia in synergy formation and demonstrate a previously unknown component of impaired feedforward control in Parkinson's disease reflected in the reduced and delayed anticipatory synergy adjustments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.