ArticleClinical biochemistry2012
Proteomics-based identification of α-enolase as a potential prognostic marker in cholangiocarcinoma.
Article in Clinical biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- TRPC5OS induces tumorigenesis by increasing ENO1-mediated glucose uptake in breast cancer.Translational oncology · 2022Article
- Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer.Oncology letters · 2020Article
- ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance.Gastroenterology research and practice · 2018Article
- Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells.Parasitology international · 2017Article
- [Role of enolase 1 in hepatocellular carcinoma and possible mechanism].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Article
- FBXW7 negatively regulates ENO1 expression and function in colorectal cancer.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Molecular Targets in Biliary Carcinogenesis and Implications for Therapy.The oncologist · 2015Review
- Enolase-1 is a therapeutic target in endometrial carcinoma.Oncotarget · 2015Article
- Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway.Journal of hematology & oncology · 2015Article
- An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma.International journal of genomics · 2015Review
- Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids in vitro.PloS one · 2015Article
- Effects of α-enolase (ENO1) over-expression on malignant biological behaviors of AGS cells.International journal of clinical and experimental medicine · 2015Article
- Identification of novel biomarker candidates for the immunohistochemical diagnosis of cholangiocellular carcinoma.Molecular & cellular proteomics : MCP · 2014Article
- Cancer biomarker discovery for cholangiocarcinoma: the high-throughput approaches.Journal of hepato-biliary-pancreatic sciences · 2014Review
- Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma.Molecular cancer · 2014Article
- Article
- Comparative membrane proteomic analysis between lung adenocarcinoma and normal tissue by iTRAQ labeling mass spectrometry.American journal of translational research · 2014Article
- Biological Entanglement-Like Effect After Communication of Fish Prior to X-Ray Exposure.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
- Retraction · 2015-11-28Duplication of/in Image · Error in Image · Euphemisms for Duplication ·
- Retracted
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo investigate the association of expression status of α-enolase (ENO1) and clinicopathological outcomes of CCA patients. DESIGN AND
methodsTwo-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) were used to compare differential expressed protein profiles of four human CCA cell lines and H69, a non-malignant biliary cell line, as a control. Immunohistochemical analysis was carried out in tissue-microarray of human CCA tissues (n=301).
resultsWe identified ENO1 in all CCA cell lines but not H69 by proteomics based. About 75% of patients with CCA showed over-expression of ENO1 in hyperplastic bile duct and the tumors compared with that in tumor-adjacent normal tissue counterparts. Moreover, over-expression of ENO1 is significantly associated with poor prognosis and tumor invasion of CCA patients.
conclusionsENO1 may serve as a prognostic marker to monitor the disease progression of these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.