ArticleJournal of the Academy of Nutrition and Dietetics2012
Inadequate dietary intake in patients with thalassemia.
Article in Journal of the Academy of Nutrition and Dietetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07204015 (Body Composition in Pediatric Patients With Thalassemia Major Attending Assiut University Children's Hospital), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Body Composition in Pediatric Patients With Thalassemia Major Attending Assiut University Children's Hospital
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Guidelines for the Standard Monitoring of Patients With Thalassemia: Report of the Thalassemia Longitudinal Cohort.Journal of pediatric hematology/oncology · 2015Guideline
- Impact of SNP Variants in PON-1 or UGT1A1 on Iron Chelation Therapy Outcomes and Zinc Status in Thalassemia Major Patients.Biological trace element research · 2026Article
- Nutritional deficiencies among adults with beta thalassemia major in Vietnam.Public health nutrition · 2025Article
- Association of healthy eating behaviours and comorbidity on quality of life among adults with beta-thalassemia major: a moderation analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Vitamin D Deficiency as a Debatable Modulator of Outcomes in Transfusion-Dependent Thalassemia; An Overview of the Latest Findings: A Narrative Review.Health science reports · 2025Article
- Two risk factors for hypozincemia in diabetic β-thalassemia patients: Hepatitis C and deferasirox.PloS one · 2024Article
- Correlation of Magnesium Level with Cardiac and Hepatic Hemosiderosis Measured by T2*MRI Technique and Age in Patients with Thalassemia Major.International journal of hematology-oncology and stem cell research · 2023Article
- Nutritional studies in patients with β-thalassemia major: A short review.Acta bio-medica : Atenei Parmensis · 2023Review
- Article
- Assessment of the Nutritional Status, Bone Mineralization, and Anthropometrics of Children with Thalassemia Major.Medeniyet medical journal · 2021Article
- Evaluation of effective factors in the acceptance of mobile health technology using the unified theory of acceptance and use of technology (UTAUT), case study: Blood transfusion complications in thalassemia patients.Medical journal of the Islamic Republic of Iran · 2020Article
- Final Height and Endocrine Complications in Patients with β-Thalassemia Intermedia: Our Experience in Non-Transfused Versus Infrequently Transfused Patients and Correlations with Liver Iron Content.Mediterranean journal of hematology and infectious diseases · 2019Article
- A contemporary therapeutic approach to bone disease in beta-thalassemia - a review.Journal of frailty, sarcopenia and falls · 2018Review
- Zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia.Nutrients · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPatients with thalassemia have low circulating levels of many nutrients, but the contribution of dietary intake has not been assessed.
objectiveOur objective was to assess dietary intake in a large contemporary sample of subjects with thalassemia.
designA prospective, longitudinal cohort study using a validated food frequency questionnaire was conducted. PARTICIPANTS/
settingTwo hundred and twenty-one subjects (19.7±11.3 years, 106 were female) were categorized into the following age groups: young children (3 to 7.9 years), older children/adolescents (8 to 18.9 years), and adults (19 years or older); 78.8% had β-thalassemia and 90% were chronically transfused. This study took place at 10 hematology outpatient clinics in the United States and Canada.
main outcome measuresWe conducted a comparison of intake with US Dietary Reference Intakes and correlated dietary intake of vitamin D with serum 25-OH vitamin D and dietary iron with total body iron stores. STATISTICAL ANALYSES PERFORMED: Intake was defined as inadequate if it was less than the estimated average requirement. χ(2), Fisher's exact, and Student's t test were used to compare intake between age categories and logistic regression analysis to test the relationship between intake and outcomes, controlling for age, sex, and race.
resultsMore than 30% of subjects consumed inadequate levels of vitamin A, D, E, K, folate, calcium, and magnesium. The only nutrients for which >90% of subjects consumed adequate amounts were riboflavin, vitamin B-12, and selenium. Dietary inadequacy increased with increasing age group (P<0.01) for vitamins A, C, E, B-6, folate, thiamin, calcium, magnesium, and zinc. More than half of the sample took additional supplements of calcium and vitamin D, although circulating levels of 25-OH vitamin D remained insufficient in 61% of subjects. Dietary iron intake was not related to total body iron stores.
conclusionsSubjects with thalassemia have reduced intake of many key nutrients. These preliminary findings of dietary inadequacy are concerning and support the need for nutritional monitoring to determine which subjects are at greatest risk for nutritional deficiency. Future research should focus on the effect of dietary quality and nutritional status on health outcomes in thalassemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.