ArticleAlcoholism, clinical and experimental research2012
Ethanol preference in Drosophila melanogaster is driven by its caloric value.
Article in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Evolution of Plasticity in Response to Ethanol Between Recently Separated Populations ofEcology and evolution · 2026Article
- Ethanol Behavioral Responses inCold Spring Harbor protocols · 2023Article
- The Promise of an Evolutionary Perspective of Alcohol Consumption.Neuroscience insights · 2023Review
- Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation.Scientific reports · 2021Article
- Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.Cell reports · 2021Article
- Alcohol-induced Aggression.Neuroscience insights · 2021Review
- Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.Addiction biology · 2020Article
- Absolute ethanol intake predicts ethanol preference inThe Journal of experimental biology · 2020Article
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Dairy Products Added to Rearing Media Negatively Effect Drosophila melanogaster (Diptera: Drosophilidae) Egg Production and Larval Development.Journal of insect science (Online) · 2018Article
- Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster.Heredity · 2018Article
- Monitoring food preference inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Dairy Products Added in Media Affect the Development of Drosophila melanogaster (Diptera: Drosophilidae).Journal of insect science (Online) · 2018Article
- The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans.Molecular psychiatry · 2018Article
- Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies inFrontiers in physiology · 2018Review
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- The CApillary FEeder Assay Measures Food Intake in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2017Article
- Review
- Key Odorants Regulate Food Attraction inFrontiers in behavioral neuroscience · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPerhaps the most difficult thing to ascertain concerning the behavior of another animal is its motivation. The motivation underlying the preference of Drosophila melanogaster for ethanol (EtOH)-rich food has long been ascribed to its value as a food. A recently introduced idea is that, as in humans, the pharmacological effects of EtOH also motivate the fly to choose EtOH-rich food over nonalcoholic food.
methodsFlies are given a choice between pipets that contain liquid food and liquid food supplemented with EtOH. In some experiments, carbohydrates are added to the non-EtOH-containing food to balance the calories for EtOH.
resultsWe confirm that D. melanogaster indeed prefer food that is supplemented with EtOH. However, if the alternative food choice is isocaloric, D. melanogaster usually do not show any preference for a 10% EtOH solution. Even after EtOH preference has been established, it can be completely reversed if the alternative food is calorically supplemented. This occurs even when the carbohydrate solution used to balance calories is not gustatorily attractive. Furthermore, if the alternative food contains more calories than the EtOH food, the flies will prefer the non-EtOH food. We go on to show that during the preference assay that EtOH in the fly does not exceed 4 mM, which in mammals is a nonintoxicating dose.
conclusionsWe conclude that preference for EtOH in this assay arises not from the pharmacological effects of EtOH but rather because of its nutritive value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.