ReviewDrugs & aging2012
Medication-related falls in the elderly: causative factors and preventive strategies.
Review in Drugs & aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 4 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Executive summary of the guideline for prescribing opioid analgesics for chronic non-cancer pain (third edition) by the Japan Society of Pain Clinicians.Journal of anesthesia · 2025Guideline
- Systematic Review of Patients' Perceptions of the Contributing Factors That Led to Falling in Acute Care Hospitals During Their Hospitalisation.Nursing open · 2025Pooled it
- Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline.Canadian family physician Medecin de famille canadien · 2018Guideline
- A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting.Clinical interventions in aging · 2014Pooled it
- Patterns of drug prescriptions in an orthogeriatric ward as compared to orthopaedic ward: results from the Trondheim Hip Fracture Trial-a randomised clinical trial.European journal of clinical pharmacology · 2017Trial
- Trial
- Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: a cluster randomized trial.European journal of pain (London, England) · 2014Trial
- An individually-tailored multifactorial intervention program for older fallers in a middle-income developing country: Malaysian Falls Assessment and Intervention Trial (MyFAIT).BMC geriatrics · 2014Trial
- Falls in the general elderly population: a 3- and 6- year prospective study of risk factors using data from the longitudinal population study 'Good ageing in Skane'.BMC geriatrics · 2013Trial
- Randomised Evaluation of Sleep in Cognitive Impairment Trial (REST)-Protocol for a Feasibility Study of a Digital Cognitive Behavioural Therapy for Insomnia Intervention.International journal of environmental research and public health · 2026Article
- Opioid prescribing practices in the U.S. and subsequent falls: a scoping review protocol.Systematic reviews · 2026Article
- Discriminating Between Fallers and Non-Fallers Using Kinematic Data from the Heel2Toe™ Wearable Sensor.Sensors (Basel, Switzerland) · 2026Article
- Article
- Gabapentinoid use and inpatient falls in hospitalized adults: a propensity score-matched case-control study.Archives of medical science : AMS · 2026Article
- Medication Mindfulness: Implementation and Evaluation of a Single-Site, 6-Month Deprescribing Intervention for Patients on Hemodialysis.Kidney360 · 2025Article
- Low-Dose Subarachnoid Anesthesia Combined with PENG and FLCN Blocks Reduces Hypotensive Episodes Without Compromising Anesthetic Depth and Duration in Hip Fracture Surgery: A Retrospective Observational Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Effects of cannabis smoke and oral Δ9THC on cognition in young adult and aged rats.Psychopharmacology · 2025Article
- Convergent Validity of the Lower Quarter Y Balance Test Against Two-Step and Timed Up and Go Tests in Thai Older Adults with and Without Locomotive Syndrome.International journal of environmental research and public health · 2025Article
- Clinical Integration and Evaluation of the STrategic Optimization of Prescription Medication Use in Patients on HemoDialysis (STOPMed-HD) Intervention.Canadian journal of kidney health and disease · 2025Article
- Predicting future fallers in Parkinson's disease using kinematic data over a period of 5 years.NPJ digital medicine · 2024Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
People are living to older age. Falls constitute a leading cause of injuries, hospitalization and deaths among the elderly. Older people fall more often for a variety of reasons: alterations in physiology and physical functioning, and the use (and misuse) of medications needed to manage their multiple conditions. Pharmacological factors that place the elderly at greater risk of drug-related side effects include changes in body composition, serum albumin, total body water, and hepatic and renal functioning. Drug use is one of the most modifiable risk factors for falls and falls-related injuries. Fall-risk increasing drugs (FRIDs) include drugs for cardiovascular diseases (such as digoxin, type 1a anti-arrhythmics and diuretics), benzodiazepines, antidepressants, antiepileptics, antipsychotics, antiparkinsonian drugs, opioids and urological spasmolytics. Psychotropic and benzodiazepine drug use is most consistently associated with falls. Despite the promise of a more favourable side-effect profile, evidence shows that atypical antipsychotic medications and selective serotonin reuptake inhibitor antidepressants do not reduce the risk of falls and hip fractures. Despite multiple efforts with regards to managing medication-associated falls, there is no clear evidence for an effective intervention. Stopping or lowering the dose of psychotropic drugs and benzodiazepines does work, but ensuring a patient remains off these drugs is a challenge. Computer-assisted alerts coupled with electronic prescribing tools are a promising approach to lowering the risk of falls as the use of information technologies expands within healthcare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.