ArticleClinical practice and epidemiology in mental health : CP & EMH2012
Psychiatric symptoms and quality of life in systemic sclerosis.
Article in Clinical practice and epidemiology in mental health : CP & EMH, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Systematic review and meta-analysis of the effectiveness of rehabilitation interventions on upper limb function in patients with systemic sclerosis.Frontiers in medicine · 2026Pooled it
- Does Guided Written Disclosure Reduce Distress and Improve Psychological Functioning in Patients with Skin Diseases?International journal of environmental research and public health · 2022Trial
- Characterisation of Systemic Sclerosis in a Jordanian Cohort: Clinical Features, Diagnostic Patterns, and Health-Related Quality of Life.Mediterranean journal of rheumatology · 2026Article
- Clinical advances and multifactorial pathophysiological mechanisms of neuropsychiatric comorbidity in systemic sclerosis.Frontiers in immunology · 2026Review
- Understanding spiritual well-being in patients with systemic sclerosis and its effect on the illness: a scoping review.Clinical rheumatology · 2025Article
- Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations.Molecular medicine (Cambridge, Mass.) · 2024Article
- Psychological features of systemic sclerosis: results from an observational study.Frontiers in medicine · 2024Article
- Impact of a resilience-building energy management intervention for people with systemic sclerosis: a mixed methods study.Rheumatology advances in practice · 2024Article
- Exercise as a multi-modal disease-modifying medicine in systemic sclerosis: An introduction by The Global Fellowship on Rehabilitation and Exercise in Systemic Sclerosis (G-FoRSS).Best practice & research. Clinical rheumatology · 2021Review
- Anxiety, Depression, and Obsessive-compulsive Disorder in a Recently Diagnosed Case of Systemic Sclerosis.Cureus · 2019Article
- Association between cortisol levels and pain threshold in systemic sclerosis and major depression.Rheumatology international · 2018Observational
- Role of redoximiRs in fibrogenesis.Redox biology · 2016Review
- Light emitting diode-generated blue light modulates fibrosis characteristics: fibroblast proliferation, migration speed, and reactive oxygen species generation.Lasers in surgery and medicine · 2015Article
- Correlates and responsiveness to change of measures of skin and musculoskeletal disease in early diffuse systemic sclerosis.Arthritis care & research · 2014Observational
- NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents.Archives of dermatological research · 2014Review
- The association between different kinds of exercise and quality of life in the long term. Results of a randomized controlled trial on the elderly.Clinical practice and epidemiology in mental health : CP & EMH · 2014Article
- Article
- Quality of life, cortisol blood levels and exercise in older adults: results of a randomized controlled trial.Clinical practice and epidemiology in mental health : CP & EMH · 2014Article
- Oxidative Stress and Skin Fibrosis.Current pathobiology reports · 2014Review
- Sailing can improve quality of life of people with severe mental disorders: results of a cross over randomized controlled trial.Clinical practice and epidemiology in mental health : CP & EMH · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSystemic sclerosis (SSc) is a rare conjunctive tissue disorder characterized by fibrosis of the skin and internal organs, and vascular obliteration phenomena. Patients with SSc often experience elevated symptoms of psychological distress, determined by the disfiguration, the pain, the fatigue sensation, and the difficult in daily life occupations. The characteristics of the disease may influence the perceived quality of life (QoL) in people with SSc.
methodsThis is a narrative review aiming to define the amount of impairment of Quality of Life in patients with Systemic Sclerosis and the component of this impairment due to depressive or other psychiatric symptoms. The search of the significant articles was carried out in PubMed for the key words "Psychiatric symptoms and Systemic Sclerosis"; "Quality of life and Systemic Sclerosis"; "Depressive Disorders and Systemic Sclerosis".
resultsPsychiatric symptoms are frequents in patients with SSc, but pain, fatigue, disability, body changes don't appear to explain the high prevalence of psychiatric comorbidity in SSc. Many studies founded a significant impairment in SSc patients' QoL, and despite the undeniable correlation between physical symptoms and SSc patients' QoL, mental health was found significantly impaired. DISCUSSION: The high rate of depression seems to strictly correlate with poor quality of life, and this finding needs more research to establish the cause of such a correlation. Patients' point of view regarding their health-related QoL could help physicians to enlarge the knowledge about physical and mental correlates of the disease, and to fit therapies as patient required. Particular attention must be given to provide the patient with correct information, in order to mitigate the anxious state on disease course, and to enhance coping skills of the patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.