Evidence map›Paper›PMID 22550272›Full record

ArticleAmerican journal of respiratory cell and molecular biology2012

Treatment option(s) for pulmonary lymphangioleiomyomatosis: progress and current challenges.

Vera P Krymskaya

Registry-linked trialAbstract readEditorialComment
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02061397 (The Safety of Simvastatin), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02061397 phase1 / phase2completednot on this mapstarted 2014, after this paper: background citation

The Safety of Simvastatin (SOS) in Patients With Pulmonary Lymphangioleiomyomatosis (LAM) and With Tuberous Sclerosis Complex (TSC)

TypeinterventionalSponsorUniversity of PennsylvaniaRan2014 to 2019Enrolled10ConditionsLymphangioleiomyomatosis, Tuberous Sclerosis ComplexArmsSimvastatin, Sirolimus Oral Product, Everolimus Oral Product
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Vera P Krymskaya

Funding

Role of p70 S6 Kinase in Regulating LAM Cell GrowthR01HL071106 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2002 to 2010
$2.5M
The Role of TSC2 and Rho GTPases in LAMR01HL090829 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2008 to 2011
$1.6M
NHLBI NIH HHS 2R01 HL071106NHLBI NIH HHS R01 HL071106NHLBI NIH HHS R01 HL090829
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HumansLung NeoplasmsLymphangioleiomyomatosis

Identifiers

PMID22550272
PMCPMC3359910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.